Forster H V, Dempsey J A, Chosy L W
J Appl Physiol. 1975 Jun;38(6):1067-72. doi: 10.1152/jappl.1975.38.6.1067.
This study has assessed the regulation of arterial blood and cerebrospinal fluid acid-base status in seven healthy men, at 250 m altitude and after 5 and 10-11 days sojourn at 4,300 m altitude (PaO2 = 39 mmHg day 1 to 48 mmHg day 11). We assumed that observed changes in lumbar spinal fluid acid-base status paralleled those in cisternal CSF, under these relatively steady-state conditions. Ventilatory acclimatization during the sojourn (-14 mmHg PaCO2 at day 11) was accompanied by: 1) reductions in [HCO3-] (-5 to -7 meq/1) which were similar in arterial blood and CSF; 2) substantial, yet incomplete, compensation (70-75%) of both CSF and blood pH; and 3) a level of CSF pH which was maintained significantly alkaline (+0.05 +/- 0.01) to normoxic control values. These data at 4,300 m confirmed and extended our previous findings for more moderate conditions of chronic hypoxia. It was postulated that the magnitude and time course of pH compensation in the CSF during chronic hypoxia and/or hypocapnia are determined by corresponding changes in plasma [HCO2-].
本研究评估了7名健康男性在海拔250米处以及在海拔4300米处停留5天和10 - 11天后（第1天PaO2 = 39 mmHg至第11天PaO2 = 48 mmHg）动脉血和脑脊液酸碱状态的调节情况。我们假定，在这些相对稳定的状态下，观察到的腰段脊髓液酸碱状态的变化与脑池脑脊液的变化相似。停留期间的通气适应（第11天PaCO2降低14 mmHg）伴随着：1）[HCO3-]降低（-5至-7 meq/1），动脉血和脑脊液中的降低情况相似；2）脑脊液和血液pH值均有显著但不完全的代偿（70 - 75%）；3）脑脊液pH值维持在比常氧对照值显著碱性的水平（+0.05±0.01）。在4300米处获得的数据证实并扩展了我们之前关于更中度慢性缺氧情况的研究结果。据推测，慢性缺氧和/或低碳酸血症期间脑脊液中pH代偿的幅度和时间进程由血浆[HCO2-]的相应变化决定。
