Innocenti P, Fucito G, Ferracuti S, Leardi M G, Cruccu G
Dipartimento di Scienze Neurologiche, Università di Roma, La Sapienza.
Boll Soc Ital Biol Sper. 1990 Mar;66(3):239-45.
In the search for reliable indirect indices of pain sensation, interest has recently focused on the nociceptive flexion reflex and late components of the brain evoked potentials. In ten volunteers with sciatica, the nociceptive flexion reflex (RIII) and the late component (N150-P220) of the evoked potentials were recorded, with the subjects at rest and during pain produced by the Lasegue manoeuvre. In recordings with the subjects at rest, both responses were stable. During the Lasegue manoeuvre, the RIII response was markedly suppressed, with a mean reduction in area of 40% (P less than 0.001). In contrast, the amplitude of the N150-P220 components did not change significantly. Our results indicate that, of the two parameters tested, RIII alone is a reliable index for measuring pain sensation.
在寻找可靠的疼痛感觉间接指标的过程中，最近人们的兴趣集中在伤害性屈曲反射和脑诱发电位的晚期成分上。对10名患有坐骨神经痛的志愿者，记录了他们在静息状态以及在拉塞格动作引起疼痛时的伤害性屈曲反射（RIII）和诱发电位的晚期成分（N150-P220）。在受试者静息状态下的记录中，两种反应均稳定。在拉塞格动作过程中，RIII反应明显受到抑制，面积平均减少40%（P<0.001）。相比之下，N150-P220成分的振幅没有明显变化。我们的结果表明，在测试的两个参数中，仅RIII是测量疼痛感觉的可靠指标。
