Doyle T D, Proctor J B
J Assoc Off Anal Chem. 1975 Mar;58(2):276-82.
Potassium guaiacolsulfonate, a highly polar, acidic substance, is readily eluted by chloroform from a pH 4.5 Celite column in the form of its ion-pair with trihexylamine, thereby effecting facile separation from other pharmaceuticals. The sulfonic acid is then back-extracted into aqueous alkali and determined spectrophotometrically. Assay of standard solutions by this procedre averaged 100.44 plus or minus 0.81%. The method was applied successfully to 4 commercial cough preparations containing a variety of other drugs.
愈创木酚磺酸钾是一种高极性酸性物质，在pH 4.5的硅藻土柱上，它能以与三己胺形成的离子对形式被氯仿轻易洗脱，从而与其他药物实现轻松分离。然后将磺酸反萃取到碱性水溶液中，并进行分光光度测定。用该方法对标准溶液进行测定，平均值为100.44%±0.81%。该方法已成功应用于4种含有多种其他药物的市售止咳制剂。
