Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7709-13. doi: 10.1002/anie.201303282. Epub 2013 Jun 20.
Jobs on the side: Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone N(ε)-methyllysine demethylases are capable of catalyzing the de-N-alkylation of groups other than N-methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.
底物选择性研究表明，生物医学领域重要的组蛋白 N(ε)-甲基赖氨酸去甲基酶 JmjC 家族成员能够催化除 N-甲基以外的基团的去 N-烷基化反应，并且能够催化形成稳定的羟化产物的反应。这组酶在结合偏好上的差异可能有助于选择性抑制剂的设计。
