偶然孔道：静息毛囊中的 Cav1.2 和干细胞激活。
The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles.
机构信息
Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
出版信息
Genes Dev. 2013 Jun 15;27(12):1315-7. doi: 10.1101/gad.223172.113.
The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incompletely understood. In the June 1, 2013, issue of Genes & Development, Yucel and colleagues (pp. 1217-1222) reported the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gated, L-type calcium channel, is expressed in hair follicle stem cells and contributes to anagen re-entry but does so in a calcium flux-independent fashion.
毛囊经历一个终生的发育周期，这取决于激活和抑制信号的整合，这些信号调节和指导多能上皮干细胞的增殖和分化。在成熟皮肤中，使休止期毛囊重新进入毛发生长期（即激活期）的效应器和机制仍不完全清楚。在 2013 年 6 月 1 日的《基因与发育》杂志上，Yucel 及其同事（第 1217-1222 页）报道了一个出人意料的发现，即 Cav1.2（一种在功能明确的电压门控、L 型钙通道中起孔形成亚单位作用的蛋白）在毛囊干细胞中表达，并有助于激活期的重新进入，但这种作用不依赖于钙离子流。
Zotero 插件