Stachowicz-Stencel Teresa, Synakiewicz Anna, Owczarzak Anna, Sliwinska Aleksandra, Lysiak-Szydlowska Wieslawa, Balcerska Anna
Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, Poland.
Contemp Oncol (Pozn). 2012;16(2):165-9. doi: 10.5114/wo.2012.28797. Epub 2012 May 29.
The goal of this study was to evaluate the activities of erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of glutathione (GSH) and ischemia-modified albumin (IMA), as potential markers in different histopathologic types of pediatric neoplasms. No studies on this subject have been reported to date.
SOD, GSH-Px, GSH, and IMA were measured before oncologic treatment in 129 children with neuroblastoma (NB), soft tissue sarcomas (STS), brain tumors, Hodgkin's disease (HD), and acute leukemias, and in 30 healthy controls.
The statistical significance of SOD was observed in patients with brain tumors (median 1840.2 U/g Hb, p = 0.0500). The level of GSH was significantly higher in patients with NB (median 6.38 U/g Hb, p = 0.0031) and leukemias (5.16 U/g Hb, p = 0.0200). IMA was statistically significant in cases of STS, NB, and leukemias compared to healthy children (p = 0.0244, p = 0.0069, and p = 0.0000, respectively). The activity of GSH-Px was not statistically significant.
The antioxidant barrier in all types of pediatric cancers is disturbed. None of the measured parameters was specific enough to represent a reliable marker for any particular histopathologic type of children's neoplasm.
本研究的目的是评估红细胞超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性，以及谷胱甘肽（GSH）和缺血修饰白蛋白（IMA）的水平，作为小儿肿瘤不同组织病理学类型的潜在标志物。迄今为止，尚未有关于该主题的研究报道。
在129例患有神经母细胞瘤（NB）、软组织肉瘤（STS）、脑肿瘤、霍奇金病（HD）和急性白血病的儿童以及30名健康对照者进行肿瘤治疗前，测量其SOD、GSH-Px、GSH和IMA水平。
在脑肿瘤患者中观察到SOD具有统计学意义（中位数1840.2 U/g Hb，p = 0.0500）。NB患者（中位数6.38 U/g Hb，p = 0.0031）和白血病患者（5.16 U/g Hb，p = 0.0200）的GSH水平显著更高。与健康儿童相比，STS、NB和白血病患者的IMA具有统计学意义（分别为p = 0.0244、p = 0.0069和p = 0.0000）。GSH-Px的活性无统计学意义。
所有类型的小儿癌症中的抗氧化屏障均受到干扰。所测量的参数均不够特异，不足以代表任何特定组织病理学类型儿童肿瘤的可靠标志物。
