从担子菌纲真菌中分离出的多糖的抗癌特性。
Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class.
作者信息
Lemieszek Marta, Rzeski Wojciech
机构信息
Department of Medical Biology, Institute of Agricultural Medicine, Lublin, Poland.
出版信息
Contemp Oncol (Pozn). 2012;16(4):285-9. doi: 10.5114/wo.2012.30055. Epub 2012 Sep 29.
Abstract
Basidiomycete mushrooms represent a valuable source of biologically active compounds with anticancer properties. This feature is primarily attributed to polysaccharides and their derivatives. The anticancer potential of polysaccharides is linked to their origin, composition and chemical structure, solubility and method of isolation. Moreover, their activity can be significantly increased by chemical modifications. Anticancer effects of polysaccharides can be expressed indirectly (immunostimulation) or directly (cell proliferation inhibition and/or apoptosis induction). Among the wide range of polysaccharides with documented anticancer properties, lentinan, polysaccharide-K (PSK) and schizophyllan deserve special attention. These polysaccharides for many years have been successfully applied in cancer treatment and their mechanism of action is the best known.
摘要
担子菌纲蘑菇是具有抗癌特性的生物活性化合物的宝贵来源。这一特性主要归因于多糖及其衍生物。多糖的抗癌潜力与其来源、组成、化学结构、溶解性和分离方法有关。此外，通过化学修饰可显著提高它们的活性。多糖的抗癌作用可间接表现（免疫刺激）或直接表现（抑制细胞增殖和/或诱导凋亡）。在众多已证明具有抗癌特性的多糖中，香菇多糖、多糖-K（PSK）和裂褶菌多糖值得特别关注。这些多糖多年来已成功应用于癌症治疗，其作用机制最为人所知。
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