Scarpari Marzia, Reverberi Massimo, Parroni Alessia, Scala Valeria, Fanelli Corrado, Pietricola Chiara, Zjalic Slaven, Maresca Vittoria, Tafuri Agostino, Ricciardi Maria R, Licchetta Roberto, Mirabilii Simone, Sveronis Aris, Cescutti Paola, Rizzo Roberto
Sapienza University, Dept. of Environmental Biology, P.le Aldo Moro 5, Roma, Italy.
Research Unit for Plant Pathology, Council for Agricultural Research and Economics, Rome, Italy, Roma, Italy.
PLoS One. 2017 Aug 22;12(8):e0171412. doi: 10.1371/journal.pone.0171412. eCollection 2017.
Mushrooms represent a formidable source of bioactive compounds. Some of these may be considered as biological response modifiers; these include compounds with a specific biological function: antibiotics (e.g. plectasin), immune system stimulator (e,g, lentinan), antitumor agents (e.g. krestin, PSK) and hypolipidemic agents (e.g. lovastatin) inter alia. In this study, we focused on the Chinese medicinal mushroom "yun zhi", Trametes versicolor, traditionally used for (cit.) "replenish essence and qi (vital energy)". Previous studies indicated the potential activity of extracts from culture filtrate of asexual mycelia of T. versicolor in controlling the growth and secondary metabolism (e.g. mycotoxins) of plant pathogenic fungi. The quest of active principles produced by T. versicolor, allowed us characterising an exo-polysaccharide released in its culture filtrate and naming it Tramesan. Herein we evaluate the biological activity of Tramesan in different organisms: plants, mammals and plant pathogenic fungi. We suggest that the bioactivity of Tramesan relies mostly on its ability to act as pro antioxidant molecule regardless the biological system on which it was applied.
蘑菇是生物活性化合物的重要来源。其中一些化合物可被视为生物反应调节剂；这些化合物具有特定的生物学功能，包括抗生素（如褶菌素）、免疫系统刺激剂（如香菇多糖）、抗肿瘤剂（如云芝多糖-K、蛋白多糖）和降血脂剂（如洛伐他汀）等。在本研究中，我们聚焦于传统上用于“补精益气”的中国药用蘑菇“云芝”，即杂色云芝。先前的研究表明，杂色云芝无性菌丝体培养滤液的提取物在控制植物病原真菌的生长和次级代谢（如霉菌毒素）方面具有潜在活性。对杂色云芝产生的活性成分的探索，使我们能够鉴定出其培养滤液中释放的一种胞外多糖，并将其命名为云芝聚糖。在此，我们评估云芝聚糖在不同生物体（植物、哺乳动物和植物病原真菌）中的生物活性。我们认为，无论应用于何种生物系统，云芝聚糖的生物活性主要依赖于其作为前抗氧化分子的能力。
