Sönmez Nurettin, Ton Ozlem, Arısan Serdar, Kılınç Fatih, Eken Kamile, Güney Soner
Sisli Etfal Research and Training Hospital, Istambul, Turkey.
Contemp Oncol (Pozn). 2012;16(4):356-9. doi: 10.5114/wo.2012.30069. Epub 2012 Sep 29.
Leydig cell tumors are rare testicular tumors of the male gonadal interstitium. Although uncommon, Leydig cell testicular neoplasms are the most common sex cord-stromal tumors and comprise 1-3% of all testicular neoplasms. This tumor is always benign in children and approximately 90% are benign in adults. In most cases, patients present with an incidental finding of a testicular mass on scrotal ultrasonography during evaluation of hydroceles or varicoceles or during diagnostic workup for infertility. Leydig cell tumors have been primarily managed with radical inguinal orchiectomy. However, conservative management with testis-sparing surgery in younger adults and children were reported in the literature. Here we report a case of bilateral Leydig cell tumor of the testis treated with radical orchiectomy who presented with the complaint of infertilityand no disease recurrence in followup for 9 months. The patient is currently disease-free and under androgen supplemantation for androgen insufficiency. We recommend complete exam and diagnostic workup in patients with infertility and azoospermia.
睾丸间质细胞瘤是男性性腺间质中罕见的睾丸肿瘤。尽管不常见,但睾丸间质细胞瘤是最常见的性索间质肿瘤,占所有睾丸肿瘤的1% - 3%。这种肿瘤在儿童中总是良性的,在成人中约90%为良性。在大多数情况下,患者是在评估鞘膜积液或精索静脉曲张时,或在不育症的诊断检查过程中,通过阴囊超声偶然发现睾丸肿块。睾丸间质细胞瘤主要通过根治性腹股沟睾丸切除术进行治疗。然而,文献报道了在年轻成人和儿童中采用保留睾丸手术的保守治疗方法。在此,我们报告一例因不育症就诊并接受根治性睾丸切除术治疗的双侧睾丸间质细胞瘤患者,随访9个月无疾病复发。该患者目前无疾病,因雄激素不足正在接受雄激素补充治疗。我们建议对不育症和无精子症患者进行全面检查和诊断性检查。