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儿童睾丸肿瘤:一种结合病理相关性的诊断与管理方法。

Testicular tumours in children: an approach to diagnosis and management with pathologic correlation.

作者信息

Sangüesa Cinta, Veiga Diana, Llavador Margarita, Serrano Agustín

机构信息

Radiology Department, Pediatric Imaging Section, Hospital Universitario y Politécnico La Fe, Avenida Fernando Abril Martorell 106, 46026, Valencia, Spain.

Pathological Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

出版信息

Insights Imaging. 2020 May 27;11(1):74. doi: 10.1186/s13244-020-00867-6.

Abstract

Testicular tumours are rare in children. Painless scrotal mass is the most frequent clinical presentation. Tumoural markers (alpha-fetoprotein, beta-human gonadotropin chorionic) and hormone levels (testosterone) contribute to the diagnosis and management of a testicular mass in boys. Ultrasonography is the best imaging modality to study testicular tumours. A benign tumour is suggested when ultrasonography shows a mainly cystic component, well-defined borders, echogenic rim or normal to increased echogenicity lesion when compared to the healthy testicular parenchyma. Malignant tumour is suspected when ultrasonography shows inhomogeneous, hypoechoic, not well-circumscribed or diffuse infiltration lesion. However, these ultrasonographic findings may overlap. Colour Doppler, power Doppler, elastography and contrast-enhanced ultrasonography are useful complementary methods to characterise the focal testicular lesions. Chest computerised tomography and abdominopelvic magnetic resonance are necessary to establish the extension in case of malignant proved tumours.Benign tumours are more frequent in prepuberal boys and malignant tumours in pubertal boys. Mature teratoma prepubertal-type is the most common histologic type. Testicular sparing surgery is the choice in benign tumours. Radical inguinal orchiectomy is indicated in malignant tumours. Prognostic is excellent.The purpose of our study is to show an approach to the diagnosis and management of the most frequent testicular tumours in children according to clinical manifestations, imaging findings and tumour markers levels based on histologically confirmed tumours in our hospital.

摘要

睾丸肿瘤在儿童中较为罕见。无痛性阴囊肿块是最常见的临床表现。肿瘤标志物(甲胎蛋白、β-人绒毛膜促性腺激素)和激素水平(睾酮)有助于男孩睾丸肿块的诊断和管理。超声检查是研究睾丸肿瘤的最佳影像学方法。当超声检查显示主要为囊性成分、边界清晰、有回声边缘或与健康睾丸实质相比回声正常至增强的病变时,提示为良性肿瘤。当超声检查显示不均匀、低回声、边界不清或弥漫性浸润性病变时,怀疑为恶性肿瘤。然而,这些超声检查结果可能会有重叠。彩色多普勒、能量多普勒、弹性成像和对比增强超声检查是用于鉴别睾丸局灶性病变的有用补充方法。对于确诊为恶性的肿瘤,需要进行胸部计算机断层扫描和腹部盆腔磁共振成像以确定其范围。良性肿瘤在青春期前男孩中更为常见,而恶性肿瘤在青春期男孩中更为常见。青春期前型成熟畸胎瘤是最常见的组织学类型。良性肿瘤的治疗选择是保留睾丸手术。恶性肿瘤则需行根治性腹股沟睾丸切除术。预后良好。我们研究的目的是根据我院经组织学证实的肿瘤,展示一种基于临床表现、影像学检查结果和肿瘤标志物水平对儿童最常见睾丸肿瘤进行诊断和管理的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a54f/7253550/f6021c35c6fe/13244_2020_867_Fig1_HTML.jpg

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