Kozielski Jerzy, Kaczmarczyk Grzegorz, Porębska Irena, Szmygin-Milanowska Katarzyna, Gołecki Marcin
Medical University of Silesia in Katowice, Katowice, Poland.
Contemp Oncol (Pozn). 2012;16(5):413-5. doi: 10.5114/wo.2012.31770. Epub 2012 Nov 20.
In the paper clinical cases of individuals diagnosed with lung cancer below the age of 40 years have been analyzed.
THE ANALYSIS INCLUDED: sex, age, clinical symptoms found before and at the moment of diagnosis, character of changes visible in radiological imaging, time that passed from the first symptoms to reporting to a doctor and to establishing a diagnosis, type of diagnostic method used in establishing the final diagnosis, histopathologic type of cancer, degree of cancer progression.
The results have been compared with a peer group who had been diagnosed 20 years earlier. Currently 7% of patients were diagnosed at the age of 25 or younger, whereas in the previous cohort patients in this age constituted 2%. The predominant pathological type was adenocarcinoma (currently 33%, previously 4%) in contrast to the earlier group in which 57% of patients had small cell lung cancer (57%). The incidence is equally distributed between both sexes, although there is an evident increase in female lung cancer cases. In the majority of patients the clinical presentation is a peripheral mass on chest X-ray. 20% of patients present pleural effusion on diagnosis. Patients reported the following complaints: breathlessness, chest pain, weight loss and fatigue. The majority of cases were diagnosed in advanced stages on the basis of a bronchoscopy acquired specimen. Time course from symptoms to diagnosis tends to be shorter than 20 years ago.
本文分析了40岁以下被诊断为肺癌的个体的临床病例。
分析内容包括:性别、年龄、诊断前及诊断时发现的临床症状、放射影像学可见变化的特征、从首次出现症状到就医及确诊所经过的时间、确诊所用的诊断方法类型、癌症的组织病理学类型、癌症进展程度。
将结果与20年前诊断的同龄组进行了比较。目前7%的患者在25岁或更年轻时被诊断,而在前一批队列中,这个年龄段的患者占2%。主要病理类型是腺癌(目前为33%,之前为4%),而早期组中57%的患者患有小细胞肺癌(57%)。发病率在两性间分布均衡,尽管女性肺癌病例明显增加。大多数患者的临床表现是胸部X光显示外周肿块。20%的患者在诊断时出现胸腔积液。患者报告了以下症状:呼吸急促、胸痛、体重减轻和疲劳。大多数病例是在晚期通过支气管镜获取标本诊断的。从症状到诊断的时间进程往往比20年前短。