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40岁以下患者的肺癌

Lung cancer in patients under the age of 40 years.

作者信息

Kozielski Jerzy, Kaczmarczyk Grzegorz, Porębska Irena, Szmygin-Milanowska Katarzyna, Gołecki Marcin

机构信息

Medical University of Silesia in Katowice, Katowice, Poland.

出版信息

Contemp Oncol (Pozn). 2012;16(5):413-5. doi: 10.5114/wo.2012.31770. Epub 2012 Nov 20.

Abstract

AIM OF THE STUDY

In the paper clinical cases of individuals diagnosed with lung cancer below the age of 40 years have been analyzed.

MATERIAL AND METHODS

THE ANALYSIS INCLUDED: sex, age, clinical symptoms found before and at the moment of diagnosis, character of changes visible in radiological imaging, time that passed from the first symptoms to reporting to a doctor and to establishing a diagnosis, type of diagnostic method used in establishing the final diagnosis, histopathologic type of cancer, degree of cancer progression.

RESULTS

The results have been compared with a peer group who had been diagnosed 20 years earlier. Currently 7% of patients were diagnosed at the age of 25 or younger, whereas in the previous cohort patients in this age constituted 2%. The predominant pathological type was adenocarcinoma (currently 33%, previously 4%) in contrast to the earlier group in which 57% of patients had small cell lung cancer (57%). The incidence is equally distributed between both sexes, although there is an evident increase in female lung cancer cases. In the majority of patients the clinical presentation is a peripheral mass on chest X-ray. 20% of patients present pleural effusion on diagnosis. Patients reported the following complaints: breathlessness, chest pain, weight loss and fatigue. The majority of cases were diagnosed in advanced stages on the basis of a bronchoscopy acquired specimen. Time course from symptoms to diagnosis tends to be shorter than 20 years ago.

摘要

研究目的

本文分析了40岁以下被诊断为肺癌的个体的临床病例。

材料与方法

分析内容包括:性别、年龄、诊断前及诊断时发现的临床症状、放射影像学可见变化的特征、从首次出现症状到就医及确诊所经过的时间、确诊所用的诊断方法类型、癌症的组织病理学类型、癌症进展程度。

结果

将结果与20年前诊断的同龄组进行了比较。目前7%的患者在25岁或更年轻时被诊断,而在前一批队列中,这个年龄段的患者占2%。主要病理类型是腺癌(目前为33%,之前为4%),而早期组中57%的患者患有小细胞肺癌(57%)。发病率在两性间分布均衡,尽管女性肺癌病例明显增加。大多数患者的临床表现是胸部X光显示外周肿块。20%的患者在诊断时出现胸腔积液。患者报告了以下症状:呼吸急促、胸痛、体重减轻和疲劳。大多数病例是在晚期通过支气管镜获取标本诊断的。从症状到诊断的时间进程往往比20年前短。

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