Sokal Paweł, Lebioda Andrzej, Harat Maciej, Furtak Jacek, Grzela Monika, Kabacińska Renata, Makarewicz Roman, Zieliński Piotr, Windorbska Wiesława
Department of Neurosurgery, Military Clinical Hospital, Bydgoszcz, Poland.
Contemp Oncol (Pozn). 2013;17(1):29-33. doi: 10.5114/wo.2013.33771. Epub 2013 Mar 15.
Efficacy of stereotactic radiosurgery (SRS) in the treatment in cerebral AVM's, mennigiomas, metastases, acoustic neuromas and recurrent anaplastic gliomas is well documented. The object of this work was the analysis of the results of the treatment of AVM and selected cerebral lesions with linear accelerator-based stereotactic radiosurgery.
THE LESIONS INCLUDED: 12 AVMs, 2 cavernomas, 27 meningiomas, 16 metastases, 5 acoustic neuromas, 16 gliomas in 78 patients. A mean radiation dose of 16Gy was delivered to the tumour or AVM margin and 12Gy to the tumours located in a ponto-cerebellar angle. Follow-up was 18 months.
Control of tumour growth or AVM was achieved in all cases after 6 months and radiological regression was observed in 20 cases after 12 months. The best results were noted in AVM's, meningiomas and neuromas.There were no new permanent deficits nor complications after radiosurgery requiring medicamentation.
Organization of SRS in Oncological Center in Bydgoszcz involving close co-operation of radiotherapist, neurosurgeon and physicist in the process of qualification and treatment planning is based on the best global standards. Preliminary results of treatment are consistent with the literature data. A longer follow-up is required to determine the long term efficacy and the toxicity of this treatment in our institution.
立体定向放射外科治疗(SRS)在治疗脑动静脉畸形(AVM)、脑膜瘤、转移瘤、听神经瘤和复发性间变性胶质瘤方面的疗效已有充分记录。本研究的目的是分析基于直线加速器的立体定向放射外科治疗AVM和选定脑病变的结果。
病变包括:78例患者中的12个AVM、2个海绵状血管瘤、27个脑膜瘤、16个转移瘤、5个听神经瘤、16个胶质瘤。肿瘤或AVM边缘的平均辐射剂量为16Gy,位于桥小脑角的肿瘤为12Gy。随访18个月。
6个月后所有病例的肿瘤生长或AVM均得到控制,12个月后20例出现放射学退缩。在AVM、脑膜瘤和神经瘤中观察到最佳结果。放射外科治疗后没有出现需要药物治疗的新的永久性缺陷或并发症。
比得哥什肿瘤中心的SRS组织在资格认证和治疗计划过程中涉及放射治疗师、神经外科医生和物理学家的密切合作,这是基于全球最佳标准。治疗的初步结果与文献数据一致。需要更长时间的随访来确定该治疗在本机构的长期疗效和毒性。