Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, the Netherlands.
Stress. 2013 Sep;16(5):520-30. doi: 10.3109/10253890.2013.807243. Epub 2013 Jul 9.
Even though there are indications that stress influences body temperature in humans, no study has systematically investigated the effects of stress on core and peripheral body temperature. The present study therefore aimed to investigate the effects of acute psychosocial stress on body temperature using different readout measurements. In two independent studies, male and female participants were exposed to a standardized laboratory stress task (the Trier Social Stress Test, TSST) or a non-stressful control task. Core temperature (intestinal and temporal artery) and peripheral temperature (facial and body skin temperature) were measured. Compared to the control condition, stress exposure decreased intestinal temperature but did not affect temporal artery temperature. Stress exposure resulted in changes in skin temperature that followed a gradient-like pattern, with decreases at distal skin locations such as the fingertip and finger base and unchanged skin temperature at proximal regions such as the infra-clavicular area. Stress-induced effects on facial temperature displayed a sex-specific pattern, with decreased nasal skin temperature in females and increased cheek temperature in males. In conclusion, the amplitude and direction of stress-induced temperature changes depend on the site of temperature measurement in humans. This precludes a direct translation of the preclinical stress-induced hyperthermia paradigm, in which core temperature uniformly rises in response to stress to the human situation. Nevertheless, the effects of stress result in consistent temperature changes. Therefore, the present study supports the inclusion of body temperature as a physiological readout parameter of stress in future studies.
尽管有迹象表明压力会影响人体体温，但尚无研究系统地调查过压力对核心体温和外周体温的影响。因此，本研究旨在使用不同的测量指标来研究急性心理社会应激对体温的影响。在两项独立的研究中，男性和女性参与者分别接受了标准化的实验室应激任务（Trier 社会应激测试，TSST）或非应激对照任务。测量了核心体温（肠和颞动脉）和外周体温（面部和皮肤体温）。与对照条件相比，应激暴露降低了肠温，但不影响颞动脉温度。应激暴露导致皮肤温度发生变化，呈现出梯度样模式，指尖和指根等远端皮肤部位的温度降低，而 infra-clavicular 等近端区域的皮肤温度不变。应激对面部温度的影响表现出性别特异性模式，女性的鼻皮肤温度降低，男性的颊部温度升高。总之，应激引起的体温变化的幅度和方向取决于体温测量的部位。这排除了将临床前应激引起的体温升高范式直接转化为人类情况的可能性，在该范式中，核心体温会因应激而均匀升高。然而，应激确实会导致一致的体温变化。因此，本研究支持将体温作为未来研究中应激的生理测量参数之一。
