乙型肝炎病毒抑制干扰素介导的抗病毒免疫：研究进展概述。
Suppression of interferon-mediated antiviral immunity by hepatitis B virus: an overview of research progress.
机构信息
West Campus Hospital of Shandong University, Jinan, China.
出版信息
Scand J Immunol. 2013 Sep;78(3):230-7. doi: 10.1111/sji.12086.
PMID:23790137
Abstract
Interferon (IFN)-α is an indispensable drug for hepatitis B treatment in clinical settings. However, hepatitis B virus (HBV) can attenuate IFN-mediated antiviral responses to avoid being inhibited or cleared. Much progress has been made in exploring how the IFN-induced anti-HBV effect is inhibited. This review examines and summarizes new advances regarding the molecular mechanism underlying the HBV-induced suppression of type I IFN-mediated antiviral immunity.
摘要
干扰素（IFN）-α 是临床治疗乙型肝炎不可或缺的药物。然而，乙型肝炎病毒（HBV）可以减弱 IFN 介导的抗病毒反应，以避免被抑制或清除。在探索 IFN 诱导的抗 HBV 作用如何被抑制方面已经取得了很大进展。本文综述了 HBV 诱导的 I 型 IFN 介导的抗病毒免疫抑制的分子机制的新进展。
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