苏丹人群中白细胞介素 10 和 CCL5 单核苷酸多态性与结核病的关联。
Association of IL-10 and CCL5 single nucleotide polymorphisms with tuberculosis in the Sudanese population.
机构信息
Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.
Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
出版信息
Trop Med Int Health. 2013 Sep;18(9):1119-1127. doi: 10.1111/tmi.12141. Epub 2013 Jun 21.
OBJECTIVE
To investigate the genetic determinants for developing tuberculosis in Sudan.
METHODS
Case study of 232 patients with tuberculosis and 206 healthy matched controls from Sudan. In the study population, three single nucleotide polymorphisms (SNPs) in the promoter regions of CCL5 and two in the promoter region of IL-10 were genotyped using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). These five SNPs influence the expression of these genes.
RESULTS
There were significant differences in allele distribution for CCL5 -28 C/G (rs 2280788) and IL-10 -592 A/C (rs1800872) in patients with tuberculosis compared with healthy controls.
CONCLUSION
This indicates that the genotypes obtained for CCL5 and IL-10 are associated with an increased risk of developing active TB.
目的
探究苏丹人群结核病发病的遗传决定因素。
方法
对来自苏丹的 232 例结核病患者和 206 例健康匹配对照进行病例研究。在研究人群中，采用聚合酶链反应和限制性片段长度多态性（PCR-RFLP）方法对 CCL5 和 IL-10 启动子区域的三个单核苷酸多态性（SNPs）和两个单核苷酸多态性进行基因分型。这五个 SNPs 影响这些基因的表达。
结果
与健康对照组相比，结核病患者 CCL5-28 C/G（rs2280788）和 IL-10-592 A/C（rs1800872）的等位基因分布存在显著差异。
结论
这表明 CCL5 和 IL-10 的基因型与活动性结核病的发病风险增加有关。
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