Alqumber Mohammed A A, Mandal Raju K, Haque Shafiul, Panda Aditya K, Akhter Naseem, Ali Arif
Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha, Saudi Arabia.
Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
PLoS One. 2013 Dec 23;8(12):e83422. doi: 10.1371/journal.pone.0083422. eCollection 2013.
The CC chemokine ligand 5 (CCL5), plays a key role in the inflammatory response by recruiting mononuclear cells during tuberculosis (TB) infection. Association studies of CCL5 -28 C>G (rs2280788) polymorphism and TB risk have shown inconsistent and contradictory results among different ethnic populations. The aim of this meta-analysis is to investigate the association between CCL5 -28 C>G polymorphism and TB susceptibility.
We performed quantitative synthesis for published studies based upon association between CCL5 -28 C>G polymorphism and TB risk from PubMed (Medline), EMBASE web databases. The meta-analysis was performed and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all genetic models.
A total of six studies including 1324 TB cases and 1407 controls were involved in this meta-analysis. Variant allele (G vs. C: p = 0.257; OR = 1.809, 95% CI = 0.649 to 5.043), heterozygous (CG vs. CC: p = 0.443; OR = 1.440, 95% CI = 0.567 to 3.658) and homozygous (GG vs. CC: p = 0.160; OR = 5.140, 95% CI = 0.524 to 50.404) carriers did not show increased risk compare with those individual with the CC genotype. Similarly, no associations were found in the dominant (GG+CG vs. CC: p = 0.295; OR = 1.802, 95% CI = 0.599 to 5.412) and recessive (GG vs. CC+CG: p = 0.188; OR = 3.533, 95% CI = 0.541 to 23.085) models.
Overall findings of this meta-analysis suggest that genetic polymorphism -28 C>G in CCL5 is not associated with increased TB risk. However, future larger studies with group of populations will be needed to analyze the relationship between the CCL5 -28 C>G polymorphism and risk of TB.
CC趋化因子配体5（CCL5）在结核病（TB）感染期间通过募集单核细胞在炎症反应中起关键作用。CCL5 -28 C>G（rs2280788）多态性与TB风险的关联研究在不同种族人群中显示出不一致和相互矛盾的结果。本荟萃分析的目的是研究CCL5 -28 C>G多态性与TB易感性之间的关联。
我们基于来自PubMed（Medline）、EMBASE网络数据库的CCL5 -28 C>G多态性与TB风险之间的关联对已发表的研究进行定量综合分析。进行荟萃分析并计算所有遗传模型的合并比值比（OR）和95%置信区间（95%CI）。
本荟萃分析共纳入6项研究，包括1324例TB病例和1407例对照。与CC基因型个体相比，变异等位基因（G对C：p = 0.257；OR = 1.809，95%CI = 0.649至5.043）、杂合子（CG对CC：p = 0.443；OR = 1.440，95%CI = 0.567至3.658）和纯合子（GG对CC：p = 0.160；OR = 5.140，95%CI = 0.524至50.404）携带者未显示出风险增加。同样，在显性（GG + CG对CC：p = 0.295；OR = 1.802，95%CI = 0.599至5.412）和隐性（GG对CC + CG：p = 0.188；OR = 3.533，95%CI = 0.541至23.085）模型中未发现关联。
本荟萃分析的总体结果表明，CCL5中-28 C>G的基因多态性与TB风险增加无关。然而，未来需要对更多人群进行更大规模的研究，以分析CCL5 -28 C>G多态性与TB风险之间的关系。
