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Lack of an additive effect between the deletions of Klf5 and Nkx3-1 in mouse prostatic tumorigenesis.

作者信息

Xing Changsheng, Fu Xiaoying, Sun Xiaodong, Dong Jin-Tang

出版信息

J Genet Genomics. 2013 Jun 20;40(6):315-8. doi: 10.1016/j.jgg.2013.04.005. Epub 2013 May 2.

DOI:10.1016/j.jgg.2013.04.005
PMID:23790631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3978631/
Abstract
摘要

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Lack of an additive effect between the deletions of Klf5 and Nkx3-1 in mouse prostatic tumorigenesis.在小鼠前列腺肿瘤发生过程中，Klf5和Nkx3-1基因缺失之间不存在累加效应。
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2
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Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models.Tmprss2-ERG基因融合与Nkx3.1缺失之间的遗传相互作用不会增强小鼠模型中的前列腺肿瘤发生。
PLoS One. 2015 Mar 17;10(3):e0120628. doi: 10.1371/journal.pone.0120628. eCollection 2015.
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Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis.Nkx3.1的缺失导致前列腺肿瘤发生过程中离散下游靶基因的激活。
Oncogene. 2009 Sep 17;28(37):3307-19. doi: 10.1038/onc.2009.181. Epub 2009 Jul 13.
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Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion.局限性前列腺萎缩、前列腺上皮内瘤变及腺癌中NKX3.1蛋白表达降低：与Gleason评分及8号染色体短臂缺失的相关性
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Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesis.Nkx3.1功能丧失促进前列腺癌发生过程中氧化损伤增加。
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引用本文的文献

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Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways.Klf5基因缺失通过多种致癌信号通路促进由Pten基因缺失引发的管腔型小鼠前列腺肿瘤。
Neoplasia. 2014 Nov 20;16(11):883-99. doi: 10.1016/j.neo.2014.09.006. eCollection 2014 Nov.
2
Krüppel-like factor 5: a novel biomarker for lymph node metastasis and recurrence in supraglottic squamous cell laryngeal carcinoma.Krüppel样因子5：声门上型喉鳞状细胞癌淋巴结转移和复发的新型生物标志物。
Tumour Biol. 2014 Jan;35(1):623-9. doi: 10.1007/s13277-013-1086-3. Epub 2013 Aug 23.

本文引用的文献

1
Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis.Nkx3.1 和 Myc 在小鼠和人前列腺肿瘤发生中相互调控共同的靶基因。
J Clin Invest. 2012 May;122(5):1907-19. doi: 10.1172/JCI58540. Epub 2012 Apr 9.
2
Mouse models of prostate cancer.前列腺癌的小鼠模型。
Prostate Cancer. 2011;2011:895238. doi: 10.1155/2011/895238. Epub 2011 Feb 23.
3
Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.雌激素通过非经典途径调节肿瘤生长，该途径包括转录因子 ERβ 和 KLF5。
Sci Signal. 2011 Apr 12;4(168):ra22. doi: 10.1126/scisignal.2001551.
4
MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.MYC 过表达诱导前列腺上皮内瘤形成和 Nkx3.1 在小鼠腔上皮细胞中的丢失。
PLoS One. 2010 Feb 25;5(2):e9427. doi: 10.1371/journal.pone.0009427.
5
Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta.在转化生长因子β背景下，KLF5对上皮细胞增殖中MYC转录的相反作用。
J Biol Chem. 2009 Oct 9;284(41):28243-28252. doi: 10.1074/jbc.M109.036160. Epub 2009 Aug 14.
6
Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer.人类前列腺癌中转录因子ATBF1的频繁体细胞突变。
Nat Genet. 2005 Apr;37(4):407-12. doi: 10.1038/ng1528. Epub 2005 Mar 6.
7
Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee.基因工程小鼠的前列腺病理学：定义与分类。人类癌症联盟前列腺病理学委员会巴尔港会议的共识报告。
Cancer Res. 2004 Mar 15;64(6):2270-305. doi: 10.1158/0008-5472.can-03-0946.
8
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.小鼠Pten肿瘤抑制基因的前列腺特异性缺失会导致转移性前列腺癌。
Cancer Cell. 2003 Sep;4(3):209-21. doi: 10.1016/s1535-6108(03)00215-0.
9
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases.Nkx3.1；Pten基因双突变小鼠会发展出浸润性前列腺腺癌并伴有淋巴结转移。
Cancer Res. 2003 Jul 15;63(14):3886-90.
10
KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer.KLF5在前列腺癌中经常缺失和下调，但很少发生突变。
Prostate. 2003 May 1;55(2):81-8. doi: 10.1002/pros.10205.