National Institute of Vegetable and Tea Science, National Agriculture and Food Research Organization, 360 Kusawa, Ano, Tsu, Mie 514-2392, Japan.
Food Chem. 2013 Nov 15;141(2):1192-5. doi: 10.1016/j.foodchem.2013.03.058. Epub 2013 Mar 25.
Allyl isothiocyanate, a chief component of mustard oil, exhibits anticancer effects in both cultured cancer cells and animal models. The accumulation of the N-acetylcysteine conjugate of allyl isothiocyanate, the final metabolite of allyl isothiocyanate, in urine was evaluated in rats that were orally coadministered allyl isothiocyanate with fluids (e.g., water, green tea, milk, and 10% ethanol) or corn oil. The N-acetylcysteine conjugate of allyl isothiocyanate content in urine when allyl isothiocyanate (2 or 4μmol) was coadministered with corn oil or milk showed a greater increase (1.4±0.22 or 2.7±0.34μmol or 1.2±0.32 or 2.5±0.36μmol, 1.6- to 1.8-fold or 1.5-fold, respectively) than when allyl isothiocyanate (2 or 4μmol) was coadministered with water (0.78±0.10 or 1.7±0.17μmol). This result demonstrates that corn oil and milk enhance the absorption of allyl isothiocyanate in rats.
丙烯基异硫氰酸酯是芥末油的主要成分，在培养的癌细胞和动物模型中均表现出抗癌作用。评估了大鼠口服给予丙烯基异硫氰酸酯与水（例如水、绿茶、牛奶和 10％乙醇）或玉米油共给药时丙烯基异硫氰酸酯的 N-乙酰半胱氨酸轭合物在尿液中的积累。当与玉米油或牛奶共给予丙烯基异硫氰酸酯（2 或 4μmol）时，尿液中丙烯基异硫氰酸酯的 N-乙酰半胱氨酸轭合物含量显示出更大的增加（1.4±0.22 或 2.7±0.34μmol 或 1.2±0.32 或 2.5±0.36μmol，分别为 1.6-1.8 倍或 1.5 倍）与当丙烯基异硫氰酸酯（2 或 4μmol）与水（0.78±0.10 或 1.7±0.17μmol）共给药时。这一结果表明，玉米油和牛奶增强了大鼠对丙烯基异硫氰酸酯的吸收。
