Austeng Marit Erna, Akre Harriet, Øverland Britt, Abdelnoor Michael, Falkenberg Eva-Signe, Kværner Kari Jorunn
Østfold Hospital Trust, Department of Otorhinolaryngology/Head and Neck Surgery, Norway.
Int J Pediatr Otorhinolaryngol. 2013 Aug;77(8):1329-32. doi: 10.1016/j.ijporl.2013.05.027. Epub 2013 Jun 20.
To determine the prevalence of otitis media with effusion (OME) in children with Down syndrome (DS), and the associated to hearing loss at the age of 8 years.
A national population based clinical study of all children with DS born in Norway in 2002.
OME was found in 20 out of 52 (38%) children. Those with OME had a significant lower hearing level with a mean pure tone average (PTA) of 33.4 dB HL compared to children with no OME whose mean PTA was 21.7 dB HL (p < 0.0001). Verified hearing loss above 25 dB HL in the better hearing ear was found in 12 out of the 20 with OME, compared to 5 out 31 without OME.
The findings of this present study uncover the increased risk of OME in eight year old children with DS as current otitis media was found in one of three. This reduced hearing ability in children with DS due to OME at age of 8 strongly emphasizes the need for optimal treatment and follow up to optimize hearing rehabilitation. The findings are further supported by the population based study design, the focus on the narrow age band and the high response rate.
确定唐氏综合征（DS）患儿中耳积液（OME）的患病率，以及8岁时与听力损失的相关性。
一项基于挪威2002年出生的所有DS患儿的全国性临床研究。
52名儿童中有20名（38%）发现有OME。与无OME的儿童相比，有OME的儿童听力水平显著较低，平均纯音听阈（PTA）为33.4 dB HL，而无OME儿童的平均PTA为21.7 dB HL（p < 0.0001）。在20名有OME的儿童中，12名较好耳听力损失超过25 dB HL得到证实，而在31名无OME的儿童中，这一数字为5名。
本研究结果揭示了8岁DS患儿患OME的风险增加，因为当前发现三分之一的患儿患有中耳炎。8岁时因OME导致DS患儿听力能力下降，强烈强调需要进行最佳治疗和随访，以优化听力康复。基于人群的研究设计、对狭窄年龄范围的关注以及高应答率进一步支持了这些发现。
