Department of Psychology, University of California, Davis, 135 Young Hall, One Shields Avenue, Davis, CA 95616, USA.
Neuron. 2013 Jun 19;78(6):1127-37. doi: 10.1016/j.neuron.2013.04.018.
Recent findings have ignited a controversy over whether the hippocampus is critical for visual perception as well as memory. Some studies have shown that hippocampal damage impairs perception of scenes, but others found no evidence for hippocampal involvement. These studies measured perception as a unitary phenomenon, but recent findings indicate that perceptual discriminations can be based on two kinds of information: states of perceiving local differences or global strength of relational match. In the current study, we separated state- and strength-based perception using a change detection paradigm with scenes. Patients with selective hippocampal damage exhibited significant reductions in strength-based perception but showed spared state-based responses. In a follow-up neuroimaging study, hippocampal activation linearly tracked confidence in strength-based perception, and was not differentially associated with state-based responses. The hippocampus therefore plays a selective role in perception, contributing high-resolution strength information possibly through its role in the representation of relational information.
最近的研究结果引发了一场争议，即海马体是否对视觉感知和记忆都至关重要。一些研究表明，海马体损伤会损害对场景的感知，但其他研究并未发现海马体参与的证据。这些研究将感知作为一个整体现象进行测量，但最近的研究结果表明，感知辨别可以基于两种信息：感知局部差异的状态或关系匹配的全局强度。在当前的研究中，我们使用场景的变化检测范式将基于状态和基于强度的感知分开。选择性海马体损伤的患者在基于强度的感知中表现出显著的降低，但表现出基于状态的反应不受影响。在后续的神经影像学研究中，海马体的激活与基于强度的感知的信心呈线性关系，并且与基于状态的反应没有差异相关。因此，海马体在感知中发挥着选择性的作用，通过其在关系信息表示中的作用，提供高分辨率的强度信息。
