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剖析内侧颞叶:区分回忆与熟悉感

Unpacking the Medial Temporal Lobe: Separating Recollection and Familiarity.

作者信息

Yonelinas Andrew P

机构信息

Center for Neuroscience & Center for Mind and Brain, Department of Psychology, Davis, California, USA.

出版信息

Hippocampus. 2025 Sep;35(5):e70033. doi: 10.1002/hipo.70033.

DOI:10.1002/hipo.70033
PMID:40919742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12416122/
Abstract

Our understanding of how the medial temporal lobe (MTL) contributes to human cognition has advanced enormously over the past half a century. My work in the 1990s characterizing the role of recollection and familiarity processes in episodic memory led me to study the MTL's role in these two memory processes. In the current paper, I provide a personal commentary in which I describe the motivating ideas, as well as the invaluable impact of mentors, colleagues, and students that led to a series of studies showing that conscious recollection is critically dependent on the hippocampus, whereas familiarity-based judgments are dependent on regions such as the perirhinal cortex.

摘要

在过去的半个世纪里,我们对内侧颞叶(MTL)如何影响人类认知的理解有了巨大的进展。我在20世纪90年代开展的工作,旨在描述回忆和熟悉过程在情景记忆中的作用,这促使我去研究MTL在这两种记忆过程中的作用。在本文中,我进行了个人评论,描述了激发研究的想法,以及导师、同事和学生所产生的宝贵影响,这些研究表明,有意识的回忆严重依赖于海马体,而基于熟悉度的判断则依赖于嗅周皮质等区域。

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本文引用的文献

1
Recollection and familiarity support auditory working memory in a manner analogous to visual working memory.记忆和熟悉度以类似于视觉工作记忆的方式支持听觉工作记忆。
Cognition. 2025 Jan;254:105987. doi: 10.1016/j.cognition.2024.105987. Epub 2024 Oct 26.
2
The amygdala is not necessary for the familiarity aspect of recognition memory.杏仁核对于再认记忆的熟悉性方面并非必需。
Nat Commun. 2023 Dec 7;14(1):8109. doi: 10.1038/s41467-023-43906-8.
3
Prefrontal and Medial Temporal Lobe Cortical Contributions to Visual Short-Term Memory.前额叶和内侧颞叶皮质对视觉短期记忆的贡献。
J Cogn Neurosci. 2022 Dec 1;35(1):27-43. doi: 10.1162/jocn_a_01937.
4
Functional Specialization of the Medial Temporal Lobes in Human Recognition Memory: Dissociating Effects of Hippocampal versus Parahippocampal Damage.人类识别记忆中内侧颞叶的功能特化:海马体与旁海马体损伤的分离效应。
Cereb Cortex. 2022 Apr 5;32(8):1637-1652. doi: 10.1093/cercor/bhab290.
5
Material Specificity Drives Medial Temporal Lobe Familiarity But Not Hippocampal Recollection.材料特异性驱动内侧颞叶的熟悉感,但不驱动海马体的回忆。
Hippocampus. 2017 Feb;27(2):194-209. doi: 10.1002/hipo.22683. Epub 2016 Dec 26.
6
The medial temporal lobe supports sensing-based visual working memory.内侧颞叶支持基于感知的视觉工作记忆。
Neuropsychologia. 2016 Aug;89:485-494. doi: 10.1016/j.neuropsychologia.2016.07.011. Epub 2016 Jul 12.
7
Selective lesion to the entorhinal cortex leads to an impairment in familiarity but not recollection.内嗅皮层的选择性损伤会导致熟悉感受损,但不会影响回忆。
Brain Cogn. 2016 Apr;104:82-92. doi: 10.1016/j.bandc.2016.02.005. Epub 2016 Mar 11.
8
Declarative and nondeclarative memory: multiple brain systems supporting learning and memory.陈述性记忆和非陈述性记忆:支持学习和记忆的多个大脑系统。
J Cogn Neurosci. 1992 Summer;4(3):232-43. doi: 10.1162/jocn.1992.4.3.232.
9
Recognition errors suggest fast familiarity and slow recollection in rhesus monkeys.恒河猴的识别错误表明其快速熟悉和缓慢回忆。
Learn Mem. 2013 Jul 17;20(8):431-7. doi: 10.1101/lm.029223.112.
10
Detecting changes in scenes: the hippocampus is critical for strength-based perception.检测场景变化:海马体对于基于强度的感知至关重要。
Neuron. 2013 Jun 19;78(6):1127-37. doi: 10.1016/j.neuron.2013.04.018.