氨基苄醇和硝基苄醇对叙利亚仓鼠胚胎细胞的形态学转化与细胞间通讯相关。

Morphological transformation of Syrian hamster embryo cells by aminobenzyl alcohols and nitrobenzyl alcohols is correlated with intercellular communication.

作者信息

Mikalsen S O

机构信息

Laboratory for Environmental and Occupational Cancer, Norwegian Radium Hospital, Oslo.

出版信息

Cancer Lett. 1990 Jul 31;52(3):203-8. doi: 10.1016/0304-3835(90)90188-4.

DOI:10.1016/0304-3835(90)90188-4

PMID:2379142

Abstract

Two aminobenzyl alcohols (ABAs) and 3 nitrobenzyl alcohols (NBAs) were studied in the Syrian hamster embryo (SHE) cell transformation system. All compounds induced statistically significant increases in morphological transformation of SHE cells. 2-ABA and 3-ABA induced dose-dependent increases in transformation, while the transformation frequencies for 2-NBA and 4-NBA decreased when concentrations were increased above 0.2 mM. When tested in an intercellular communication assay using dye transfer between SHE cells, 2-ABA inhibited communication, and 2-NBA and 4-NBA enhanced communication. Thus, the inverse dose-response of 2-NBA related to an increased intercellular communication.

摘要

在叙利亚仓鼠胚胎（SHE）细胞转化系统中研究了两种氨基苄醇（ABA）和三种硝基苄醇（NBA）。所有化合物均使SHE细胞的形态转化在统计学上显著增加。2-ABA和3-ABA诱导转化呈剂量依赖性增加，而当浓度增加到0.2 mM以上时，2-NBA和4-NBA的转化频率降低。在使用SHE细胞间染料转移的细胞间通讯试验中进行测试时，2-ABA抑制通讯，而2-NBA和4-NBA增强通讯。因此，2-NBA的剂量反应呈反比与细胞间通讯增加有关。