Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancer Lett. 2013 Oct 10;339(2):153-8. doi: 10.1016/j.canlet.2013.06.008. Epub 2013 Jun 18.
Altered metabolism is fundamental to the growth and survival of cancer cells. Pyruvate kinase M2 (PKM2), a key enzyme in cancer metabolism, has been demonstrated to play a central role not only in metabolic reprogramming but also in direct regulation of gene expression and subsequent cell cycle progression. This review outlines the current understanding of PKM2 protein kinase activity and regulatory mechanisms underlying PKM2 expression, enzymatic activity, and nuclear localization, thus highlighting PKM2 as a potential therapeutic target.
代谢改变是癌细胞生长和存活的基础。丙酮酸激酶 M2（PKM2）是癌症代谢中的关键酶，已被证明不仅在代谢重编程中发挥核心作用，而且在直接调节基因表达和随后的细胞周期进程中也发挥核心作用。本文概述了目前对 PKM2 蛋白激酶活性和调节机制的理解，包括 PKM2 表达、酶活性和核定位的调节机制，从而突出了 PKM2 作为潜在治疗靶点的潜力。
