锦葵（Malva sylvestris var. mauritiana）叶中一种酸性多糖的结构及抗补体活性

Structure and anticomplementary activity of an acidic polysaccharide from the leaves of Malva sylvestris var. mauritiana.

作者信息

Gonda R, Tomoda M, Shimizu N, Yamada H

机构信息

Kyoritsu College of Pharmacy, Tokyo, Japan.

出版信息

Carbohydr Res. 1990 May 1;198(2):323-9. doi: 10.1016/0008-6215(90)84302-b.

DOI:10.1016/0008-6215(90)84302-b

PMID:2379192

Abstract

A main acidic polysaccharide preparation was isolated from the leaves of Malva sylvestris L. var mauritiana Mill. It is composed of L-rhamnose, D-galactose, D-galacturonic acid, and D-glucuronic acid in the molar ratio of 22:6:22:11, and it contains 7.7% peptide. It was homogeneous by electrophoresis and gel chromatography, which gave a value of 11,000 as molecular weight. The structure of the polysaccharide component was elucidated by methylation analysis and partial hydrolysis. The substance showed considerable anticomplementary activity.

摘要

从锦葵科植物圆叶锦葵（Malva sylvestris L. var mauritiana Mill.）的叶子中分离出一种主要的酸性多糖制剂。它由L-鼠李糖、D-半乳糖、D-半乳糖醛酸和D-葡萄糖醛酸组成，摩尔比为22:6:22:11，并且含有7.7%的肽。通过电泳和凝胶色谱分析表明其具有均一性，分子量为11,000。通过甲基化分析和部分水解阐明了多糖成分的结构。该物质表现出相当强的抗补体活性。