Tomoda M, Matsumoto K, Shimizu N, Gonda R, Ohara N, Hirabayashi K
Kyoritsu College of Pharmacy, Tokyo, Japan.
Biol Pharm Bull. 1994 Sep;17(9):1161-4. doi: 10.1248/bpb.17.1161.
An acidic polysaccharide, called peonan PA, was isolated from the root of Paeonia lactiflora PALLAS. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 6.0 x 10(4). Peonan PA is composed of L-arabinose: D-galactose: D-galacturonic acid in the molar ratio of 2:1:10, in addition to small amounts of O-acetyl groups and peptide moieties. About forty percent of the hexuronic acid residues in peonan PA exist as methyl esters. Reduction of carboxyl groups, methylation analysis, lithium degradation and nuclear magnetic resonance studies indicated that its main structural features involve both alpha-1,5-linked L-arabino-beta-3,6-branched D-galactan type and alpha-1,4-linked D-galacturonan type structural units. The polysaccharide exhibited remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and considerable anti-complementary activity.
从芍药根中分离出一种酸性多糖，称为芍药聚糖PA。它在电泳和凝胶色谱上均一，其分子量估计为6.0×10⁴。芍药聚糖PA由L-阿拉伯糖、D-半乳糖、D-半乳糖醛酸按摩尔比2:1:10组成，此外还有少量的O-乙酰基和肽部分。芍药聚糖PA中约40%的己糖醛酸残基以甲酯形式存在。羧基还原、甲基化分析、锂降解和核磁共振研究表明，其主要结构特征涉及α-1,5-连接的L-阿拉伯糖-β-3,6-分支的D-半乳聚糖型和α-1,4-连接的D-半乳糖醛酸型结构单元。该多糖在碳清除试验中表现出显著的网状内皮系统增强活性和相当的抗补体活性。
