Fukuzumi T, Waki N, Kanakura Y, Nagoshi J, Hirota S, Yoshikawa K, Kitamura Y
Department of Dermatology, Osaka University Medical School, Japan.
Exp Hematol. 1990 Aug;18(7):843-7.
Although precursors of mast cells are derived from the bone marrow, phenotypes of mast cells are influenced by the tissues in which final differentiation occurs. Connective tissue-type mast cells (CTMC) and mucosal mast cells (MMC) are different in morphological, biochemical, immunological, and functional criteria. The purpose of the present study was to obtain information about the differentiation process of MMC. First, we compared changes in irradiation susceptibility in mice during the differentiation process of CTMC and MMC. The decrease in irradiation susceptibility was remarkable in the CTMC differentiation process, but it was moderate in that of MMC. Some morphologically identifiable CTMC in the peritoneal cavity had proliferative potential and were highly radioresistant, whereas such a radioresistant population of MMC was not detectable in the gastric mucosa. Second, we estimated the turnover of CTMC and MMC by determining the proportion of mast cells that were labeled with continuously administered bromodeoxyuridine. The turnover of MMC was significantly faster than that of CTMC. The absence of the radioresistant mast cell population in the gastric mucosa appeared to be related to the short life span of MMC.
尽管肥大细胞的前体来源于骨髓，但其表型受最终分化所在组织的影响。结缔组织型肥大细胞（CTMC）和黏膜肥大细胞（MMC）在形态、生化、免疫和功能标准方面存在差异。本研究的目的是获取有关MMC分化过程的信息。首先，我们比较了CTMC和MMC分化过程中小鼠辐射敏感性的变化。在CTMC分化过程中，辐射敏感性的降低很显著，但在MMC分化过程中则较为适度。腹腔中一些形态上可识别的CTMC具有增殖潜力且对辐射高度抗性，而在胃黏膜中未检测到如此抗辐射的MMC群体。其次，我们通过测定连续给予溴脱氧尿苷标记的肥大细胞比例来估计CTMC和MMC的更新率。MMC的更新率明显快于CTMC。胃黏膜中缺乏抗辐射肥大细胞群体似乎与MMC的短寿命有关。
