Sonoda S, Sonoda T, Nakano T, Kanayama Y, Kanakura Y, Asai H, Yonezawa T, Kitamura Y
J Immunol. 1986 Aug 15;137(4):1319-22.
Mast cells may be classified into at least two phenotypically distinct populations: connective tissue-type mast cells (CTMC) and mucosal mast cells (MMC). Mast cells in the peritoneal cavity of mice are typical CTMC, whereas mast cells in the mucosa of the stomach show morphologic characteristics of MMC. We investigated whether CTMC may change to MMC. A single peritoneal mast cell of WBB6F1-+/+ mice was identified under the phase-contrast microscope, picked up with the micromanipulator, and injected into the stomach wall of genetically mast cell-deficient WBB6F1-W/Wv mice. The cells with histochemical and electron microscopical features of MMC developed in the mucosa, and those with histochemical features of CTMC in the muscularis propria. This directly demonstrates that a certain proportion of CTMC may function as a bipotent precursor for both MMC and CTMC.
结缔组织型肥大细胞（CTMC）和黏膜肥大细胞（MMC）。小鼠腹腔中的肥大细胞是典型的CTMC，而胃黏膜中的肥大细胞则表现出MMC的形态学特征。我们研究了CTMC是否会转变为MMC。在相差显微镜下识别出WBB6F1-+/+小鼠的单个腹腔肥大细胞，用显微操作器将其取出，并注射到遗传性肥大细胞缺陷的WBB6F1-W/Wv小鼠的胃壁中。在黏膜中出现了具有MMC组织化学和电子显微镜特征的细胞，而在固有肌层中出现了具有CTMC组织化学特征的细胞。这直接证明了一定比例的CTMC可能作为MMC和CTMC的双能前体发挥作用。
