Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin, Belfield, Dublin, 4, Ireland.
Cell Microbiol. 2013 Sep;15(9):1484-95. doi: 10.1111/cmi.12161. Epub 2013 Jul 29.
Mycobacteria are a genus of bacteria that range from the non-pathogenic Mycobacterium smegmatis to Mycobacterium tuberculosis, the causative agent of tuberculosis in humans. Mycobacteria primarily infect host tissues through inhalation or ingestion. They are phagocytosed by host macrophages and dendritic cells. Here, conserved pathogen-associated molecular patterns (PAMPs) on the surface of mycobacteria are recognized by phagocytic pattern recognition receptors (PRRs). Several families of PRRs have been shown to non-opsonically recognize mycobacterial PAMPs, including membrane-bound C-type lectin receptors, membrane-bound and cytosolic Toll-like receptors and cytosolic NOD-like receptors. Recently, a possible role for intracellular cytosolic PRRs in the recognition of mycobacterial pathogens has been proposed. Here, we discuss currentideas on receptor-mediated recognition of mycobacterial pathogens by macrophages and dendritic cells.
分枝杆菌是一类细菌，包括非致病性的耻垢分枝杆菌和导致人类结核病的结核分枝杆菌。分枝杆菌主要通过吸入或摄入感染宿主组织。它们被宿主巨噬细胞和树突状细胞吞噬。在这里，分枝杆菌表面上的保守病原体相关分子模式 (PAMP) 被吞噬细胞模式识别受体 (PRR) 识别。已经证明有几类 PRR 可以非调理性地识别分枝杆菌 PAMP，包括膜结合 C 型凝集素受体、膜结合和胞质 Toll 样受体以及胞质 NOD 样受体。最近，有人提出细胞内胞质 PRR 在识别分枝杆菌病原体中的可能作用。在这里，我们讨论巨噬细胞和树突状细胞对分枝杆菌病原体的受体介导识别的当前观点。
