Anaya-Alaminos Roberto, García-Serrano José Luis, Cantero-Hinojosa Jesús
San Cecilio, Ophthalmology , Granada , Spain and.
J Matern Fetal Neonatal Med. 2014 Apr;27(6):635-6. doi: 10.3109/14767058.2013.818648. Epub 2013 Jul 26.
To determine that slower weight premature twins have more risk to develop severe retinopathy of prematurity (ROP) than the higher weight twins. We know that the lower weight twins had less optimal intra-uterine environments than their higher weight twins. We screened 94 consecutive premature twins for ROP. We compared the lower weight twins (n = 47) against their higher weight twins (n = 47). The risk of severe ROP (ROP stage 3 or greater) was significantly higher in the lower weight twin group (p < 0.006). In the same way, in the lower weight twin group the non-perfused area of the temporal retinal artery was higher than that of the other group (an average of 1.2 diameters of the optic nerve head), in the 4-6 postnatal weeks (p < 0.004). The lower weight twin group have an increased risk of severe ROP associated with bacteremia (p = 0.045), or a weight gain less than 7 g per day in the 4-6 postnatal weeks (p = 0.013) or a supplementary postnatal oxygen >4 days (p = 0.007) compared to the higher weight twin group. We confirm Dr. Lee's work that less optimal prenatal factors, in preterm twins, increase the risk of severe ROP.
为了确定体重增长较慢的早产双胞胎比体重较重的双胞胎患严重早产儿视网膜病变（ROP）的风险更高。我们知道，体重较轻的双胞胎在子宫内的环境不如体重较重的双胞胎理想。我们对94例连续的早产双胞胎进行了ROP筛查。我们将体重较轻的双胞胎（n = 47）与其体重较重的双胞胎（n = 47）进行了比较。体重较轻的双胞胎组中严重ROP（ROP 3期或更高）的风险显著更高（p < 0.006）。同样，在出生后4 - 6周，体重较轻的双胞胎组颞侧视网膜动脉的无灌注区高于另一组（平均为视神经乳头直径的1.2倍）（p < 0.004）。与体重较重的双胞胎组相比，体重较轻的双胞胎组患严重ROP的风险增加与菌血症相关（p = 0.045），或在出生后4 - 6周体重增加少于每天7克（p = 0.013）或出生后补充氧气超过4天（p = 0.007）有关。我们证实了Lee博士的研究结果，即早产双胞胎中不太理想的产前因素会增加严重ROP的风险。
