Department of Ophthalmology, Etlik Zübeyde Hanım Women's Health Education and Research Hospital, Ankara, Turkey.
Department of Neonatology, Etlik Zübeyde Hanım Women's Health Education and Research Hospital, Ankara, Turkey.
Indian J Ophthalmol. 2019 Jun;67(6):806-810. doi: 10.4103/ijo.IJO_1197_17.
Since twin pairs with discordance have equal gestational age (GA), discordant twins may constitute an appropriate group to investigate the specific effect that birth weight (BW) has on the development of retinopathy of prematurity (ROP). The present study aims to investigate the effect of BW on any and severe stages of ROP development in twin pairs.
Fifty-two discordant twin pairs (104 preterms) born ≤32 gestational weeks, who were diagnosed with a minimum of 18% discordance between their BWs, were retrospectively analyzed. Twin pairs were separated into two groups based on the BW of each pair. The rate of any stage of ROP, Type 1 ROP, and perinatal risk factors were compared statistically among twin pairs.
The rate of any stage of ROP and Type 1 ROP was 24.0% and 4.8% in the whole group, respectively. A statistically significant difference was shown between lower and higher BW groups at any stage of ROP development (34.6% vs. 13.4%, P = 0.02). However, no difference was observed in Type 1 ROP development (7.7% vs. 1.9%, P = 0.17). No significant differences were found between twin pairs regarding neonatal morbidities. The number of small GA (SGA) infants in the smaller twin group was statistically higher than larger group and regression analysis showed that being SGA had significant correlation with any stage of ROP (odds ratio: 4.98, P = 0.02).
This study showed that BW serves an effective role at any stage of ROP development in discordant twin pairs; however, no significant difference in terms of Type 1 ROP.
由于双胎妊娠的胎儿具有相同的胎龄（GA），因此双胎妊娠中的双胎儿可能是研究出生体重（BW）对早产儿视网膜病变（ROP）发展的具体影响的合适群体。本研究旨在探讨 BW 对双胎妊娠中任何阶段和严重程度的 ROP 发展的影响。
回顾性分析了 52 对出生时胎龄≤32 周、BW 差异≥18%的双胎妊娠。根据每对 BW 将双胎分为两组，比较两组之间 ROP 各期、1 型 ROP 及围生期危险因素的发生率。
整个研究组 ROP 各期和 1 型 ROP 的发生率分别为 24.0%和 4.8%。BW 较低和较高组之间 ROP 各期的发生率存在显著差异（34.6%比 13.4%，P=0.02），但 1 型 ROP 无差异（7.7%比 1.9%，P=0.17）。两组间新生儿并发症无显著差异。较小胎的 SGA 婴儿数量明显多于较大胎，回归分析显示 SGA 与 ROP 各期均有显著相关性（比值比：4.98，P=0.02）。
本研究表明 BW 在双胎妊娠中 ROP 各期的发展中起作用，但对 1 型 ROP 无显著影响。
