Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Taipei, Taipei, Taiwan.
Int J Gynaecol Obstet. 2013 Sep;122(3):212-5. doi: 10.1016/j.ijgo.2013.03.033. Epub 2013 Jun 22.
To determine risk factors and perinatal outcomes associated with small for gestational age (SGA) neonates among healthy pregnant women.
A retrospective cohort study was conducted of 49 945 women who gave birth at Chang Gung Memorial Hospital, Taipei, Taiwan, after 24weeks of pregnancy. Idiopathic SGA newborns (n=3398) were characterized by a birth weight below the 10th percentile for mean weight corrected for GA and fetal sex.
Risk factors for idiopathic SGA newborns included hypercoiling of the umbilical cord (adjusted odds ratio [aOR], 3.3; 95% confidence interval [CI], 1.6-7.0); prior fetal death (aOR, 2.8; 95% CI, 2.0-3.9); primiparity (aOR, 1.5; 95% CI, 1.4-1.7); adolescent pregnancy (aOR, 1.5; 95% CI, 1.2-2.0), low prepregnancy weight (aOR, 1.6; 95% CI, 1.5-1.8), low prepregnancy body mass index (aOR, 1.1; 95% CI, 1.0-1.3); short stature (aOR, 1.3; 95% CI, 1.1-1.4); and entangled umbilical cord (aOR, 1.1; 95% CI, 1.0-1.3). Idiopathic SGA newborns correlated with increased risk of adverse perinatal outcomes, including fetal death, low Apgar scores, oligohydramnios, placental abruption, and admission to the neonatal intensive care unit.
Some risk factors for idiopathic SGA newborns were modifiable, suggesting potential implications for public health.
确定健康孕妇中与胎儿生长受限（SGA）相关的危险因素和围产儿结局。
对台湾长庚纪念医院 49945 名 24 周后分娩的孕妇进行回顾性队列研究。特发性 SGA 新生儿（n=3398）的特征是出生体重低于胎龄和胎儿性别校正后的平均体重第 10 百分位数。
特发性 SGA 新生儿的危险因素包括脐带过度卷曲（调整优势比[aOR]，3.3；95%置信区间[CI]，1.6-7.0）；胎儿死亡史（aOR，2.8；95% CI，2.0-3.9）；初产妇（aOR，1.5；95% CI，1.4-1.7）；青少年妊娠（aOR，1.5；95% CI，1.2-2.0），低孕前体重（aOR，1.6；95% CI，1.5-1.8），低孕前体重指数（aOR，1.1；95% CI，1.0-1.3）；身材矮小（aOR，1.3；95% CI，1.1-1.4）；脐带缠绕（aOR，1.1；95% CI，1.0-1.3）。特发性 SGA 新生儿与不良围产儿结局风险增加相关，包括胎儿死亡、低 Apgar 评分、羊水过少、胎盘早剥和新生儿重症监护病房入院。
一些特发性 SGA 新生儿的危险因素是可以改变的，这表明对公共卫生具有潜在影响。
