腰围与墨西哥裔美国家庭中2型糖尿病的发病存在遗传相关性。
Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican-American families.
作者信息
Mamtani M, Kulkarni H, Dyer T D, Almasy L, Mahaney M C, Duggirala R, Comuzzie A G, Blangero J, Curran J E
机构信息
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
出版信息
Diabet Med. 2014 Jan;31(1):31-5. doi: 10.1111/dme.12266. Epub 2013 Jul 13.
Abstract
AIMS
We aimed to determine the genetic and environmental correlation between various anthropometric indexes and incident Type 2 diabetes with a focus on waist circumference.
METHODS
We used the data on extended Mexican-American families (808 subjects, 7617.92 person-years follow-up) from the San Antonio Family Heart Study and estimated the genetic and environmental correlations of 16 anthropometric indexes with the genetic liability of incident Type 2 diabetes. We performed bivariate trait analyses using the solar software package.
RESULTS
All 16 anthropometric indexes were significantly heritable (range of heritabilities 0.24-0.99). Thirteen indexes were found to have significant environmental correlation with the liability of incident Type 2 diabetes. In contrast, only anthropometric indexes consisting of waist circumference (waist circumference, waist-hip ratio and waist-height ratio) were significantly genetically correlated (genetic correlation coefficients: 0.45, 0.55 and 0.44, respectively) with the liability of incident Type 2 diabetes. We did not observe such a correlation for BMI.
CONCLUSIONS
Waist circumference as a predictor of future Type 2 diabetes is supported by the finding that they share common genetic influences.
摘要
目的
我们旨在确定各种人体测量指标与2型糖尿病发病之间的遗传和环境相关性，重点关注腰围。
方法
我们使用了圣安东尼奥家族心脏研究中墨西哥裔美国人大家庭的数据（808名受试者，7617.92人年随访），并估计了16项人体测量指标与2型糖尿病发病遗传易感性之间的遗传和环境相关性。我们使用Solar软件包进行双变量性状分析。
结果
所有16项人体测量指标均具有显著的遗传性（遗传率范围为0.24 - 0.99）。发现有13项指标与2型糖尿病发病易感性存在显著的环境相关性。相比之下，只有包含腰围的人体测量指标（腰围、腰臀比和腰高比）与2型糖尿病发病易感性存在显著的遗传相关性（遗传相关系数分别为0.45、0.55和0.44）。我们未观察到BMI有此类相关性。
结论
腰围作为未来2型糖尿病的预测指标得到了如下发现的支持，即它们具有共同的遗传影响。
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