Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA.
Int J Epidemiol. 2010 Dec;39(6):1647-55. doi: 10.1093/ije/dyq126. Epub 2010 Aug 25.
Accumulating evidence implicates insufficient oxidative capacity in the development of type 2 diabetes. This notion has not been well tested in large, population-based studies.
To test this hypothesis, we assessed the cross-sectional association of plasma lactate, an indicator of the gap between oxidative capacity and energy expenditure, with type 2 diabetes in 1709 older adults not taking metformin, who were participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
The prevalence of type 2 diabetes rose across lactate quartiles (11, 14, 20 and 30%; P for trend <0.0001). Following adjustment for demographic factors, physical activity, body mass index and waist circumference, the relative odds of type 2 diabetes across lactate quartiles were 0.98 [95% confidence interval (CI) 0.59-1.64], 1.64 (95% CI 1.03-2.64) and 2.23 (95% CI 1.38-3.59), respectively. Furthermore, lactate was associated with higher fasting glucose among non-diabetic adults.
Plasma lactate was strongly associated with type 2 diabetes in older adults. Plasma lactate deserves greater attention in studies of oxidative capacity and diabetes risk.
越来越多的证据表明，氧化能力不足与 2 型糖尿病的发生有关。这一观点尚未在大型人群研究中得到充分验证。
为了验证这一假设，我们评估了血浆乳酸（氧化能力与能量消耗之间差距的指标）在 1709 名未服用二甲双胍的老年人中的横断面关联，这些老年人是动脉粥样硬化风险社区（ARIC）颈动脉 MRI 研究的参与者。
2 型糖尿病的患病率在乳酸四分位组中呈上升趋势（11%、14%、20%和 30%；趋势 P<0.0001）。在校正人口统计学因素、体力活动、体重指数和腰围后，乳酸四分位组的 2 型糖尿病相对比值分别为 0.98（95%置信区间 0.59-1.64）、1.64（95%置信区间 1.03-2.64）和 2.23（95%置信区间 1.38-3.59）。此外，乳酸与非糖尿病成年人的空腹血糖升高有关。
血浆乳酸与老年人 2 型糖尿病密切相关。在研究氧化能力和糖尿病风险时，血浆乳酸应得到更多关注。
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