Leng J Junhong, Liu Gongshu, Wang Jing, Li Weiqin, Liu Huihuan, She Ye, Liu Jian
Tianjin Women and Children's Health Center , Tianjin , China .
J Matern Fetal Neonatal Med. 2014 Mar;27(5):479-83. doi: 10.3109/14767058.2013.818972. Epub 2013 Jul 26.
To examine the relationship between maternal glucose challenge test (GCT) levels and fetal nutritional status index (FNSI: a ratio of child's birth weight (kg) over squared maternal height (m(2)).
A total of 2193 women from the Beichen district, Tianjin, China, who had 50 g GCT at gestational age 24-28 weeks, gave a full-term singleton birth between June 2011 and October 2012, and with both maternal height and birth weight measures are included in this report.
Approximately 28.0% of women had a GCT ≥ 7.8 mmol/L. The newborns of mothers with a GCT ≥ 7.8 mmol/L had significantly higher level of FNSI ([kg/m(2)], boys: 1.336 versus 1.296, p < 0.001; girls: 1.312 versus 1.268, p < 0.0001). Logistic regression results, after adjustment for maternal age, residence, education, nationality, history of disease and reproduction, insurance and gestational age, indicated that every unit increase in FNSI was associated with approximately threefold higher odds (OR [95% CI]: 3.6 [1.5, 8.9]) of being in GCT ≥ 7.8 mmol/L for women giving birth as boys and fivefold higher odds (5.9 [2.5, 14.1]) for giving birth as girls.
Women with a GCT ≥ 7.8 mmol/L have babies with a higher FNSI, suggesting that these infants may be overnourished before birth and may increase cardiovascular risk in their future.
研究孕妇葡萄糖耐量试验（GCT）水平与胎儿营养状况指数（FNSI：胎儿出生体重（kg）与孕妇身高平方（m²）的比值）之间的关系。
本报告纳入了2011年6月至2012年10月期间在天津市北辰区进行妊娠24 - 28周50g GCT、单胎足月分娩且有孕妇身高和出生体重测量数据的2193名妇女。
约28.0%的妇女GCT≥7.8 mmol/L。GCT≥7.8 mmol/L的母亲所生新生儿的FNSI水平显著更高（[kg/m²]，男孩：1.336对1.296，p<0.001；女孩：1.312对1.268，p<0.0001）。在对孕妇年龄、居住地、教育程度、国籍、疾病史和生育史、保险情况及孕周进行调整后，逻辑回归结果表明，FNSI每增加一个单位，生男孩的妇女GCT≥7.8 mmol/L的几率约高3倍（比值比[95%置信区间]：3.6[1.5, 8.9]），生女孩的妇女几率高5倍（5.9[2.5, 14.1]）。
GCT≥7.8 mmol/L的妇女所生婴儿的FNSI较高，提示这些婴儿在出生前可能营养过剩，且未来心血管疾病风险可能增加。
