Department of Dermatology, Memorial Sloan-Kettering Cancer Center, 160 East 53rd Street, 2nd Floor, New York, NY, 10022, U.S.A.
Br J Dermatol. 2013 Oct;169(4):848-53. doi: 10.1111/bjd.12482.
Naevogenesis is a process known to occur throughout life. To date, investigators have made conclusions about new naevi in adults based on results of cross-sectional studies.
To determine the incidence of new naevus development in adults and to describe the dermoscopic morphology of new naevi.
A cohort of 182 patients seen at the outpatient dermatology clinic at Memorial Sloan-Kettering Cancer Center between 2000 and 2009 was evaluated with baseline total body photographs. The patients were aged 17 years or older and had presented for routine follow-up surveillance examination at least 3 months after baseline total body photographs. The number of new naevi and the dermoscopic morphology of these naevi were recorded.
Of the 182 patients evaluated, 50 (27%) developed at least one new naevus during follow-up. The incidence of new naevi was 202 per 1000 person-years of follow-up. The most common types of naevi were reticular (47·1%), followed by the homogeneous (22·1%) and complex (reticuloglobular) patterns (15·4%).
Our results provide support for the theory that there are two distinct pathways of naevogenesis, a dynamic process occurring throughout life. This study demonstrates that the predominant dermoscopic morphology of newly acquired naevi in adults is reticular.
痣发生是一种已知发生于整个生命过程中的现象。迄今为止，研究人员根据横断面研究的结果得出了关于成年人中新痣的结论。
确定成年人中新痣的发生率，并描述新痣的皮肤镜形态。
对 2000 年至 2009 年间在纪念斯隆-凯特琳癌症中心皮肤科门诊就诊的 182 例患者进行了评估，这些患者在基线时接受了全身拍照。患者年龄在 17 岁及以上，在基线全身拍照后至少 3 个月进行常规随访检查。记录新痣的数量和这些痣的皮肤镜形态。
在评估的 182 例患者中，有 50 例（27%）在随访期间至少出现了 1 个新痣。新痣的发生率为每 1000 人年 202 个。最常见的痣类型是网状（47·1%），其次是均匀型（22·1%）和复杂型（网状-小球状）（15·4%）。
我们的结果支持痣发生有两种不同途径的理论，这是一个贯穿整个生命过程的动态过程。本研究表明，成年人中新获得的痣的主要皮肤镜形态是网状。
