Dermatology Research Centre, School of Medicine, The University of Queensland, Australia.
Australas J Dermatol. 2011 Nov;52(4):248-53. doi: 10.1111/j.1440-0960.2011.00798.x. Epub 2011 Jul 28.
Dermoscopic understanding of naevus characteristics is essential baseline knowledge for identifying early malignant changes.
This cross-sectional study includes 34 patients (56% female, mean age 48 years) at high risk of melanoma (personal or a first degree family member with history of melanoma) and 31 moderate/low melanoma risk volunteers (55% female, mean age 37 years) recruited at the Princess Alexandra Hospital, Brisbane, between October 2009 and March 2010. Participants received full body and individual dermoscopic imaging of clinically significant naevi (≥2 mm on the back of male/female and lower limbs of female and ≥5 mm at other body sites). Dermoscopic patterns of naevi were compared between people at high versus moderate/low melanoma risk according to age and body site.
In both high and moderate/low risk groups, globular naevi predominated on the head/neck and abdomen/chest, reticular and non-specific naevi on the back, and non-specific pattern on the upper and lower limbs. Non-specific naevi were the most common in all age groups. In both risk groups, globular naevi were more frequent in the younger age bracket, and reticular naevi were more frequent in the older age bracket. Mixed naevus patterns were infrequent and were more common in the younger age brackets of both risk groups.
Our preliminary data shows that dermoscopic naevus patterns were similar for age and body site in people at different levels of melanoma risk, suggesting high melanoma risk does not influence dermoscopic naevus patterns.
对痣特征的皮肤镜理解是识别早期恶性变化的基本基线知识。
本横断面研究包括 2009 年 10 月至 2010 年 3 月在布里斯班亚历山德拉公主医院招募的 34 名（56%为女性，平均年龄 48 岁）高危黑色素瘤患者（个人或一级亲属有黑色素瘤病史）和 31 名中/低危黑色素瘤志愿者（55%为女性，平均年龄 37 岁）。参与者接受了全身和个体痣的临床显著皮肤镜成像（男性/女性背部≥2mm 和女性下肢≥5mm，以及其他身体部位）。根据年龄和身体部位，比较了高危与中/低危黑色素瘤人群中痣的皮肤镜模式。
在高风险和中/低风险组中，球形痣主要分布在头/颈部和腹部/胸部，网状和非特异性痣分布在背部，非特异性模式分布在上肢和下肢。在所有年龄组中，非特异性痣最常见。在两个风险组中，球形痣在较年轻的年龄组中更为常见，而网状痣在较年长的年龄组中更为常见。混合痣模式很少见，在两个风险组的较年轻年龄组中更为常见。
我们的初步数据表明，在不同黑色素瘤风险水平的人群中，皮肤镜痣模式与年龄和身体部位相似，这表明高黑色素瘤风险不会影响皮肤镜痣模式。
