Dermatology Research Centre, School of Medicine, The University of Queensland, Australia.
Australas J Dermatol. 2011 Nov;52(4):254-8. doi: 10.1111/j.1440-0960.2011.00794.x. Epub 2011 Jul 28.
BACKGROUND/OBJECTIVES: It is well recognized that the number and patterns of acquired melanocytic naevi vary with age, but little is known about naevus patterns in the elderly. This is a cross-sectional study assessing the prevalence, dermoscopic pattern and anatomical distribution of naevus subtypes in a stratified cohort aged between 60 and 89 years.
Fifty-nine patients who attended the Queensland Institute of Dermatology were recruited randomly and evenly distributed into three age groups: 60-69 years; 70-79 years; and 80-89 years. For each participant, total naevus count and morphological naevus types were recorded with respect to age, sex and anatomical location. Flat (Clark's) naevi were further subclassified according to the dermoscopic pattern as reticular, globular or structureless.
Using non-parametric methods, naevus counts in the elderly decreased due to the disappearance of reticular naevi (P < 0.05). By contrast, structureless and intradermal (Unna's and Miescher's) naevi seemed to persist even into older age. Naevi on the trunk, limbs, head and neck represented 57.6%, 31.0% and 11.3%, respectively. Notably, no reticular naevi were found on the head and neck area.
There is a progressive reduction in total naevus counts with advancing age with respect to a cohort aged greater than 60 years.
背景/目的：众所周知，获得性黑素细胞痣的数量和模式随年龄而变化，但对于老年人的痣模式知之甚少。这是一项横断面研究，评估了分层队列中年龄在 60 至 89 岁之间的痣亚型的患病率、皮肤镜模式和解剖分布。
随机招募了 59 名前往昆士兰皮肤病研究所的患者，并将其平均分配到三个年龄组：60-69 岁；70-79 岁；80-89 岁。对于每个参与者，记录了总痣计数和形态学痣类型，以及年龄、性别和解剖位置。扁平（Clark's）痣根据皮肤镜模式进一步细分为网状、球状或无结构。
使用非参数方法，由于网状痣的消失，老年人的痣计数减少（P < 0.05）。相比之下，无结构和真皮内（Unna's 和 Miescher's）痣似乎即使到了老年也能持续存在。躯干、四肢、头部和颈部的痣分别占 57.6%、31.0%和 11.3%。值得注意的是，头部和颈部没有发现网状痣。
随着年龄的增长，总痣计数相对于年龄大于 60 岁的队列逐渐减少。
