Department of Pediatrics, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey.
J Pediatr (Rio J). 2013 Jul-Aug;89(4):407-11. doi: 10.1016/j.jped.2012.12.001. Epub 2013 Jun 21.
Oxidative stress has been shown to contribute to the pathogenesis of acute and chronic lung inflammatory diseases. This article aimed to evaluate the oxidant/antioxidant status of children with acute bronchiolitis through the measurement of plasma total antioxidant capacity, total oxidant status, and oxidative stress index.
Children with acute bronchiolitis admitted to the pediatric emergency department of a university hospital between January and April of 2012 were compared with age-matched healthy controls. Patients with acute bronchiolitis were classified as mild and moderate bronchiolitis. Oxidative and antioxidative status were assessed by measurement of plasma total antioxidant capacity, total oxidant status, and oxidative stress index.
Thirty-one children with acute bronchiolitis aged between 3 months and 2 years, and 39 healthy children were included. Total oxidative status (TOS) was higher in patients with acute bronchiolitis than the control group (5.16±1.99 μmol H2O2 versus 3.78±1.78 μmol H2O2 [p=0.004]). Total antioxidant capacity (TAC) was lower in children with bronchiolitis than the control group (2.51±0.37 μmol Trolox eqv/L versus 2.75±0.39 μmol Trolox eqv/L [p=0.013]). Patients with moderate bronchiolitis presented higher TOS levels than those with mild bronchiolitis and the control group (p=0.03, p<0.001, respectively). Patients with moderate bronchiolitis had higher oxidative stress index levels than the control group (p=0.015). Oxygen saturation level of bronchiolitis patients was inversely correlated with TOS (r=-0.476, p<0.05).
The balance between oxidant and antioxidant systems is disrupted in children with moderate bronchiolitis, which indicates that this stress factor may have a role in the pathogenesis of the disease.
氧化应激被认为与急、慢性肺部炎症性疾病的发病机制有关。本文旨在通过测量血浆总抗氧化能力、总氧化状态和氧化应激指数来评估急性细支气管炎患儿的氧化剂/抗氧化剂状态。
2012 年 1 月至 4 月期间，将在大学医院儿科急诊就诊的急性细支气管炎患儿与年龄匹配的健康对照组进行比较。将急性细支气管炎患儿分为轻度和中度细支气管炎。通过测量血浆总抗氧化能力、总氧化状态和氧化应激指数来评估氧化和抗氧化状态。
共纳入 31 名年龄在 3 个月至 2 岁之间的急性细支气管炎患儿和 39 名健康儿童。与对照组相比，急性细支气管炎患儿的总氧化状态（TOS）更高（5.16±1.99 μmol H2O2 比 3.78±1.78 μmol H2O2 [p=0.004]）。细支气管炎患儿的总抗氧化能力（TAC）低于对照组（2.51±0.37 μmol Trolox eqv/L 比 2.75±0.39 μmol Trolox eqv/L [p=0.013]）。中度细支气管炎患儿的 TOS 水平高于轻度细支气管炎患儿和对照组（分别为 p=0.03、p<0.001）。中度细支气管炎患儿的氧化应激指数水平高于对照组（p=0.015）。细支气管炎患儿的血氧饱和度水平与 TOS 呈负相关（r=-0.476，p<0.05）。
中度细支气管炎患儿的氧化剂和抗氧化剂系统平衡被打破，这表明这种应激因素可能在疾病的发病机制中起作用。
