Karadag-Oncel Eda, Erel Ozcan, Ozsurekci Yasemin, Caglayik Dilek Yagci, Kaya Ali, Gozel Mustafa Gokhan, Icagasioglu Fusun Dilara, Engin Aynur, Korukluoglu Gulay, Uyar Yavuz, Elaldi Nazif, Ceyhan Mehmet
Department of Pediatrics, Pediatric Infectious Disease Unit, Faculty of Medicine, Hacettepe University.
Jpn J Infect Dis. 2014;67(1):22-6. doi: 10.7883/yoken.67.22.
In this study, we investigated the pro- and antioxidant status of patients with a pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) in terms of their role in its pathogenesis. During the study period, 34 children and 41 adults were diagnosed with CCHF. The control group consisted of healthy age- and gender-matched children and adults. Serum levels of the total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and plasma total thiol (TTL) were evaluated and compared between groups. The difference in mean TAC values between CCHF patients and healthy controls was not statistically significant (P > 0.05). Mean TOS, OSI, and TTL values were significantly lower in CCHF patients than in healthy controls (P < 0.001). Comparisons between the 2 groups revealed that mean TOS and OSI values were significantly lower in adults with CCHF than in their healthy counterparts (P < 0.001). Similarly, mean TTL levels were lower in both children and adults with CCHF when compared separately with healthy controls (P < 0.05). There was no significant difference in the mean serum TTL levels between children and adults with CCHF (P > 0.05). Our results suggest that TTL may play a more important role in CCHF pathogenesis than the other parameters investigated. The mean TOS and OSI values were higher in the control group than in CCHF patients.
在本研究中，我们从其在发病机制中的作用方面，调查了患有克里米亚-刚果出血热（CCHF）的患者的促氧化和抗氧化状态。在研究期间，34名儿童和41名成人被诊断为CCHF。对照组由年龄和性别匹配的健康儿童和成人组成。评估并比较了两组之间血清总抗氧化能力（TAC）、总氧化状态（TOS）、氧化应激指数（OSI）和血浆总巯基（TTL）水平。CCHF患者与健康对照组之间的平均TAC值差异无统计学意义（P>0.05）。CCHF患者的平均TOS、OSI和TTL值显著低于健康对照组（P<0.001）。两组之间的比较显示，患有CCHF的成人的平均TOS和OSI值显著低于其健康对照（P<0.001）。同样，与健康对照组分别比较时，患有CCHF的儿童和成人的平均TTL水平均较低（P<0.05）。患有CCHF的儿童和成人之间的平均血清TTL水平无显著差异（P>0.05）。我们的结果表明，TTL在CCHF发病机制中可能比其他研究参数发挥更重要的作用。对照组的平均TOS和OSI值高于CCHF患者。
