Rubery E D, Barlow S M, Steadman J H
Toxicology and Environmental Health Division, Department of Health, London, U.K.
Food Addit Contam. 1990 May-Jun;7(3):287-302. doi: 10.1080/02652039009373895.
The U.K. Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) provides advice to government on the safety-in-use of additives and on the possible health hazards from contaminants in food. In the past the COT has given advice on additives in descriptive rather than numerical terms; chemicals were either acceptable, temporarily acceptable or not acceptable for food use. From 1989 onwards the Committee will set acceptable intakes for new additives or existing additives under review and tolerable intakes for contaminants. These will provide guidance on levels of intake which generally should not be exceeded, and will be an aid to decisions on maximum levels of use of particular additives in specified foods. The criteria used by the COT to set quantitative estimates of acceptable and tolerable intakes are discussed.
英国食品、消费品及环境中化学品毒性委员会（COT）就食品添加剂的使用安全性以及食品中污染物可能对健康造成的危害向政府提供建议。过去，COT对添加剂的建议采用描述性而非数字形式；化学品对于食品用途而言要么是可接受的、暂时可接受的，要么是不可接受的。从1989年起，该委员会将为新的添加剂或正在审查的现有添加剂设定可接受摄入量，并为污染物设定耐受摄入量。这些将为一般不应超过的摄入量水平提供指导，并有助于就特定食品中特定添加剂的最大使用量做出决策。文中讨论了COT用于设定可接受摄入量和耐受摄入量定量估计值的标准。
