Division of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
Horm Res Paediatr. 2013;80(1):6-10. doi: 10.1159/000351809. Epub 2013 Jun 20.
To determine whether a standard daily dose of 400 IU vitamin D is sufficient to normalize vitamin D levels in infants born to vitamin D-deficient mothers.
The children were recruited from a study cohort of 68 immigrant and 51 non-immigrant pregnant women living in Stockholm. The women were monitored at 12 weeks of pregnancy, at delivery and together with their children, 6-18 months after birth. During pregnancy, most immigrant women (78%) had 25(OH)D3 levels <25 nmol/l. We here report the outcome of 25 infants born to these mothers. All infants received a daily supplementation dose of 400 IU vitamin D from 2 weeks of age.
At birth, most children in the immigrant group were vitamin D-deficient (23.3 nmol/l (12-54); mean and range) while at 6-18 months of age vitamin D levels were essentially normalized (82.8 nmol/l (38-142)) although 4 children still had subnormal levels consistent with vitamin D insufficiency.
A daily recommended supplementation dose of 400 IU vitamin D is sufficient in most children of vitamin D-deficient immigrant women living in Sweden.
确定对于维生素 D 缺乏的母亲所生的婴儿，每日标准剂量 400IU 的维生素 D 是否足以使维生素 D 水平正常化。
从居住在斯德哥尔摩的 68 名移民和 51 名非移民孕妇的研究队列中招募了这些儿童。在妊娠 12 周、分娩时以及出生后 6-18 个月时，对这些孕妇及其子女进行了监测。在妊娠期间，大多数移民妇女（78%）的 25（OH）D3 水平<25nmol/l。我们在此报告了这些母亲所生的 25 名婴儿的结果。所有婴儿从 2 周龄开始每天接受 400IU 维生素 D 的补充剂量。
在出生时，移民组的大多数儿童都存在维生素 D 缺乏（23.3nmol/l（12-54）；均值和范围），而在 6-18 个月时，维生素 D 水平基本正常化（82.8nmol/l（38-142）），尽管仍有 4 名儿童的水平仍低于正常值，提示存在维生素 D 不足。
对于居住在瑞典的维生素 D 缺乏的移民妇女的大多数儿童而言，每日推荐的 400IU 维生素 D 补充剂量是足够的。
