Hitrova-Nikolova St, Nikolov A, Vakrilova L, Yarakova N, Pramatarova T, Popivanova A, Radulova P, Jekova N, Emilova Z
Akush Ginekol (Sofiia). 2014;53(5):27-34.
Deficiency of vitamin D (25-OHD) is a health problem among prematurely born women and their newborns independently of the geographical location of the country.
To study serum levels of vitamin D in patients born before 32 weeks and their newborns at birth. To analyse the socio-demographic factors, complications of pregnancy and their relationship with vitamin D status of women.
The study has been carried out in the University hospital "Maichin dom" Sofia for the period August 2013-January 2014. 35 women who gave birth before 32 gestational week and their 41 newborns with birth weight < 1500g have been investigated. The serum level of vitamin D (25-OH D) in mother-infant pairs at birth and 8 weeks of age in infants has been investigated. The ECLIA method has been used. Serum levels of vit D (25-OHD) have been estimated as sufficient:(> 30 ng/ml), insufficient (21-29ng/ml) and deficient (< 20 ng/ml).
At delivery according to their vit D (25- OHD) serum levels 63% of the mothers are defficient /12.61 ± 4.8 ng/ml/, 28.5% are insufficient/26.66 ± 2.59/and only 8.5%/40.4 ± 8.48/sufficient with normal levels of vitamin D. For newborns data are respectively 32%/ 20.08 ± 3.69/-deficient, 49%/27.39 ± 2.70/- insufficient and 19 %- sufficient/41.6 + 10/ There is a positive correlation between mother's and children's serum levels of vitamin D (25- OHD). Statistical significant differences are observed in the levels of vitamin D and the presence of infection and preeclampsia in the mothers. During the period of the study there were no seasonal variations in vit D (25-OHD) serum levels of mother-baby pairs. All newborns received Vit D3 1334 IU/daily from 20th day of age. At eight weeks of age sufficient levels of vitamin D have 70% of the children, but 30% of the newborns remains with inadequate supplementation/27.09 ng/ml/.
91.5% of mothers are with insufficient serum levels of vitamin D (25OHD) at birth, and a deficit is present in 63% of all women. Only in 8.5% of the women had normal values. This implies more effective monitoring and vitamin D prophylaxis during pregnancy.
维生素D（25-OHD）缺乏是早产女性及其新生儿面临的一个健康问题，与国家的地理位置无关。
研究孕32周前出生的患者及其新生儿出生时的血清维生素D水平。分析社会人口学因素、妊娠并发症及其与女性维生素D状态的关系。
该研究于2013年8月至2014年1月在索非亚的“麦钦多姆”大学医院进行。对35名孕32周前分娩的女性及其41名出生体重<1500g的新生儿进行了调查。研究了母婴对出生时以及婴儿8周龄时的血清维生素D（25-OH D）水平。采用电化学发光免疫分析（ECLIA）法。维生素D（25-OHD）的血清水平被评估为充足（>30 ng/ml）、不足（21-29ng/ml）和缺乏（<20 ng/ml）。
分娩时，根据维生素D（25-OHD）血清水平，63%的母亲缺乏/12.61±4.8 ng/ml/，28.5%不足/26.66±2.59/，只有8.5%/40.4±8.48/维生素D水平正常。新生儿的数据分别为32%/20.08±3.69/-缺乏，49%/27.39±2.70/-不足，19% - 充足/41.6 + 10/。母亲和儿童的血清维生素D（25-OHD）水平之间存在正相关。在母亲的维生素D水平与感染和先兆子痫的存在之间观察到统计学显著差异。在研究期间，母婴对的维生素D（25-OHD）血清水平没有季节性变化。所有新生儿从出生第20天起每天接受1334 IU的维生素D3。在8周龄时，70%的儿童维生素D水平充足，但30%的新生儿补充不足/27.09 ng/ml/。
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