Department of Pediatrics, Child Health and Sports Center, Endocrine Clinic, Meir Medical Center, Sackler School of Medicine, Tel Aviv University, Kfar-Saba, Israel.
Horm Res Paediatr. 2013;79(6):325-32. doi: 10.1159/000348732. Epub 2013 Jun 19.
BACKGROUND/AIMS: To examine the effects of a 3-month multidisciplinary intervention on anthropometric measures, physical activity patterns and fitness, inflammatory cytokines, adipocytokines, and growth mediators in obese children.
21 obese subjects completed the 3-month intervention and were compared with 20 age-, gender- and maturity-matched controls. Subjects underwent anthropometric measurements (weight, height, BMI percentile and waist circumference), blood tests (IL-6, CRP, leptin, adiponectin, insulin, IGF-I and glucose), a progressive treadmill exercise test to evaluate fitness, and habitual activity assessment before and after the intervention.
The intervention led to a significant change of differences in body weight (-1.3 ± 4.1 vs. 2.5 ± 3.3 kg), BMI percentile (-0.96 ± 1.29 vs. 0.19 ± 0.8), waist circumference (-2.1 ± 2.7 vs. 2.9 ± 3.0 cm) and running time (149.9 ± 86.3 vs. -8.2 ± 88.0 s) in the intervention compared to control. There was a significant increase in leisure-time physical activity (Godin questionnaire, 29.04 ± 6.8 vs. -1.3 ± 9.2) and a decrease in sedentary activity (-1.4 ± 0.73 vs. 0.02 ± 0.62 h/day) in the intervention compared to control. Significant change differences in adiponectin (2,308 ± 1,640 vs. -801 ± 465 ng/ml), IGF-I (33.8 ± 37.8 vs. -1.0 ± 36.2 ng/ml), CRP (-0.06 ± 0.29 vs. 0.5 ± 0.86 mg/dl) and HOMA-IR (-0.15 ± 0.57 vs. 0.55 ± 0.84) were found in the intervention group compared to control.
Our results highlight the short-term beneficial effects of a childhood obesity multidisciplinary intervention on anthropometrics, habitual activity, fitness, inflammatory and metabolic measures. The longer-term effects of these changes on obesity-associated metabolic risks are yet to be determined.
背景/目的：研究 3 个月的多学科干预对肥胖儿童的人体测量指标、体力活动模式和体能、炎症细胞因子、脂肪细胞因子和生长介质的影响。
21 名肥胖受试者完成了 3 个月的干预，并与 20 名年龄、性别和成熟度匹配的对照组进行比较。受试者进行了人体测量（体重、身高、BMI 百分位和腰围）、血液检查（IL-6、CRP、瘦素、脂联素、胰岛素、IGF-I 和血糖）、渐进式跑步机运动测试以评估体能以及干预前后的习惯性活动评估。
干预导致体重（-1.3 ± 4.1 与 2.5 ± 3.3 kg）、BMI 百分位（-0.96 ± 1.29 与 0.19 ± 0.8）、腰围（-2.1 ± 2.7 与 2.9 ± 3.0 cm）和跑步时间（149.9 ± 86.3 与-8.2 ± 88.0 s）的差异在干预组中发生了显著变化，而在对照组中则发生了显著变化。与对照组相比，干预组的休闲时间体力活动（Godin 问卷，29.04 ± 6.8 与-1.3 ± 9.2）显著增加，久坐时间（-1.4 ± 0.73 与 0.02 ± 0.62 h/天）显著减少。与对照组相比，干预组的脂联素（2,308 ± 1,640 与-801 ± 465 ng/ml）、IGF-I（33.8 ± 37.8 与-1.0 ± 36.2 ng/ml）、CRP（-0.06 ± 0.29 与 0.5 ± 0.86 mg/dl）和 HOMA-IR（-0.15 ± 0.57 与 0.55 ± 0.84）的差异有显著变化。
我们的研究结果强调了儿童肥胖多学科干预对人体测量、习惯性活动、体能、炎症和代谢指标的短期有益影响。这些变化对肥胖相关代谢风险的长期影响仍有待确定。
