Blüher Susann, Panagiotou Grigorios, Petroff David, Markert Jana, Wagner Antje, Klemm Thorsten, Filippaios Andreas, Keller Alexandra, Mantzoros Christos S
Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.
Obesity (Silver Spring). 2014 Jul;22(7):1701-8. doi: 10.1002/oby.20739. Epub 2014 Mar 25.
Exercise improves weight status and metabolism. Irisin, a novel myokine, may be involved in the regulation of metabolic function. The effect of an exercise and dietary lifestyle intervention for 1-year on irisin, adipokines (leptin, adiponectin, resistin) and inflammatory markers (C-reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFR-II) was evaluated, and predictors of irisin levels were characterized in obese children.
Parameters were assessed at baseline and at follow-up for 65 obese children who completed the program (7-18 years, 54%boys). Their relation to weight status and metabolic risk was analyzed.
Anthropometric and metabolic parameters improved after completion of the program. Circulating irisin levels at baseline were 111.0 ± 8.0 ng ml(-1) and increased after the intervention by 12% [6%, 17%], P = 0.00003. There was no evidence for differences in irisin levels between genders and across age. Moreover, changes in irisin did not correlate with those in BMI-SDS, adipokines or inflammatory markers. Leptin decreased after the intervention (Δ5.3 ng ml(-1) , [3.2, 6.3], P = 10(-7) ). Anthropometric measures were significantly associated with leptin and inflammatory markers.
A 1-year long lifestyle intervention program is associated with improvement in anthropometric and metabolic parameters and leads to an elevation in irisin levels in obese children.
运动可改善体重状况和新陈代谢。鸢尾素是一种新型的肌动蛋白，可能参与代谢功能的调节。本研究评估了为期1年的运动和饮食生活方式干预对鸢尾素、脂肪因子（瘦素、脂联素、抵抗素）和炎症标志物（C反应蛋白（CRP）、可溶性肿瘤坏死因子受体II（sTNFR-II））的影响，并对肥胖儿童鸢尾素水平的预测因素进行了特征分析。
对65名完成该项目的肥胖儿童（7 - 18岁，54%为男孩）在基线和随访时进行参数评估。分析它们与体重状况和代谢风险的关系。
项目完成后，人体测量和代谢参数得到改善。基线时循环鸢尾素水平为111.0±8.0 ng/ml，干预后升高了12%[6%，17%]，P = 0.00003。没有证据表明性别和年龄之间鸢尾素水平存在差异。此外，鸢尾素的变化与BMI-SDS、脂肪因子或炎症标志物的变化无关。干预后瘦素水平下降（Δ5.3 ng/ml，[3.2，6.3]，P = 10⁻⁷）。人体测量指标与瘦素和炎症标志物显著相关。
为期1年的生活方式干预项目与肥胖儿童人体测量和代谢参数的改善相关，并导致鸢尾素水平升高。
