法国葡萄球菌分离株LS表型的抗性基因
Resistance Genes Underlying the LS Phenotype of Staphylococcal Isolates from France.
作者信息
Tessé Sophie, Trueba François, Berthet Nicolas, Hot Chloé, Chesneau Olivier
机构信息
HIA Val-de-Grâce, Service de Biologie Médicale, Paris, France.
Institut Pasteur, Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France.
出版信息
Antimicrob Agents Chemother. 2013 Sep;57(9):4543-4546. doi: 10.1128/AAC.00259-13. Epub 2013 Jun 24.
Abstract
There exist numerous genes disseminated by mobile elements that can confer cross-resistance to lincosamides and streptogramin A compounds in staphylococci. This study investigated the nature and means of dissemination of genes responsible for LS resistance among 24 French clinical isolates screened for reduced susceptibility to lincomycin. The (A) gene was found to be the most prevalent determinant of LS resistance, while Tn appeared to be its exclusive gene support.
摘要
存在许多由移动元件传播的基因，这些基因可使葡萄球菌对林可酰胺类和链阳菌素A化合物产生交叉耐药性。本研究调查了24株对林可霉素敏感性降低的法国临床分离株中负责LS耐药性的基因的性质和传播方式。发现（A）基因是LS耐药性最普遍的决定因素，而Tn似乎是其唯一的基因载体。
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