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Target protection as a key antibiotic resistance mechanism.靶向保护作为一种关键的抗生素耐药机制。
Nat Rev Microbiol. 2020 Nov;18(11):637-648. doi: 10.1038/s41579-020-0386-z. Epub 2020 Jun 25.
2
Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics.定植于不同抗生素暴露水平猪群的耐甲氧西林金黄色葡萄球菌分离株的流行病学和耐药性研究。
PLoS One. 2019 Nov 20;14(11):e0225497. doi: 10.1371/journal.pone.0225497. eCollection 2019.
3
Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.突变导致抗生素耐药性短暂沉默，这代表了一个重大的潜在治疗失败的原因。
mBio. 2019 Oct 29;10(5):e01755-19. doi: 10.1128/mBio.01755-19.
4
ABC-F proteins in mRNA translation and antibiotic resistance.ABC-F 蛋白在 mRNA 翻译和抗生素耐药性中的作用。
Res Microbiol. 2019 Nov-Dec;170(8):435-447. doi: 10.1016/j.resmic.2019.09.005. Epub 2019 Sep 26.
5
Comparative Genomic Analysis of Reveals Key to Hospital Adaptation and Pathogenicity.[具体研究对象]的比较基因组分析揭示医院适应性和致病性的关键。 （你提供的原文中“of”后面缺少具体内容，这里是补充完整后的翻译）
Front Microbiol. 2019 Sep 10;10:2096. doi: 10.3389/fmicb.2019.02096. eCollection 2019.
6
Ribosome protection by ABC-F proteins-Molecular mechanism and potential drug design.ABC-F 蛋白对核糖体的保护-分子机制与潜在药物设计。
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7
ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life.参与蛋白质合成、核糖体组装和抗生素耐药性的 ABCF ATPases：生命之树中的结构和功能多样化。
J Mol Biol. 2019 Aug 23;431(18):3568-3590. doi: 10.1016/j.jmb.2018.12.013. Epub 2018 Dec 28.
8
HflXr, a homolog of a ribosome-splitting factor, mediates antibiotic resistance.HflXr，一种核糖体分裂因子的同源物，介导抗生素耐药性。
Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13359-13364. doi: 10.1073/pnas.1810555115. Epub 2018 Dec 13.
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10
Structural basis for antibiotic resistance mediated by the ABCF ATPase VmlR.VmlR ABCF 型 ATP 酶介导抗生素耐药性的结构基础。
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核糖体介导的(A)表达衰减受 Vga(A)蛋白变体对抗生素耐药性特异性的影响。

Ribosome-Mediated Attenuation of (A) Expression Is Shaped by the Antibiotic Resistance Specificity of Vga(A) Protein Variants.

机构信息

Institute of Microbiology of the Czech Academy of Sciences, Vestec, Czech Republic.

Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway.

出版信息

Antimicrob Agents Chemother. 2020 Oct 20;64(11). doi: 10.1128/AAC.00666-20.

DOI:10.1128/AAC.00666-20
PMID:32816732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7577164/
Abstract

Vga(A) protein variants confer different levels of resistance to lincosamides, streptogramin A, and pleuromutilins (LSP) by displacing antibiotics from the ribosome. Here, we show that expression of (A) variants from is regulated by -regulatory RNA in response to the LSP antibiotics by the mechanism of ribosome-mediated attenuation. The specificity of induction depends on Vga(A)-mediated resistance rather than on the sequence of the riboregulator. Fine tuning between Vga(A) activity and its expression in response to the antibiotics may contribute to the selection of more potent Vga(A) variants because newly acquired mutation can be immediately phenotypically manifested.

摘要

Vga(A) 蛋白变体通过将抗生素从核糖体上置换下来，赋予了不同水平的林可酰胺类、链阳性菌素 A 和截短侧耳素（LSP）耐药性。在这里，我们表明，通过核糖体介导的衰减机制，来自 的 (A) 变体的表达受 -调节 RNA 调控，以响应 LSP 抗生素。诱导的特异性取决于 Vga(A)介导的耐药性，而不是核糖体调节剂的序列。Vga(A) 活性与其对抗生素表达之间的精细调节可能有助于选择更有效的 Vga(A)变体，因为新获得的突变可以立即表型化。