柯克斯体（Coxiella burnetii）这种严格的细胞内细菌的分子发病机制。
Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii.
机构信息
Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center College of Medicine, Bryan, Texas 77807-3260, USA.
出版信息
Nat Rev Microbiol. 2013 Aug;11(8):561-73. doi: 10.1038/nrmicro3049. Epub 2013 Jun 24.
Abstract
The agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that causes acute and chronic infections. The study of C. burnetii pathogenesis has benefited from two recent fundamental advances: improved genetic tools and the ability to grow the bacterium in extracellular media. In this Review, we describe how these recent advances have improved our understanding of C. burnetii invasion and host cell modulation, including the formation of replication-permissive Coxiella-containing vacuoles. Furthermore, we describe the Dot/Icm (defect in organelle trafficking/intracellular multiplication) system, which is used by C. burnetii to secrete a range of effector proteins into the host cell, and we discuss the role of these effectors in remodelling the host cell.
摘要
Q 热的病原体柯克斯体（Coxiella burnetii）是一种专性细胞内细菌，可引起急性和慢性感染。柯克斯体发病机制的研究得益于最近的两项重大进展：改进的遗传工具和在细胞外培养基中生长细菌的能力。在这篇综述中，我们描述了这些最新进展如何提高我们对柯克斯体入侵和宿主细胞调节的理解，包括复制允许的含柯克斯体空泡的形成。此外，我们描述了 Dot/Icm（细胞器运输/细胞内增殖缺陷）系统，该系统被柯克斯体用于将一系列效应蛋白分泌到宿主细胞中，并讨论了这些效应蛋白在重塑宿主细胞中的作用。
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