Kohler Lara J, Roy Craig R
Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA.
Department of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT, USA.
Microbes Infect. 2015 Nov-Dec;17(11-12):766-71. doi: 10.1016/j.micinf.2015.08.006. Epub 2015 Aug 29.
Coxiella burnetii utilizes a Type IV Secretion System (T4SS) to modify host endomembrane transport systems to form a unique lysosome-derived niche called the Coxiella-containing vacuole (CCV). Although the CCV has lysosomal properties, this organelle displays distinct characteristics such as homotypic fusion and a cholesterol enriched limiting membrane, in addition to robustly interacting with autophagosomes. This review describes recent advances in understanding CCV biogenesis and the mechanisms C. burnetii employs to maintain this unique compartment.
伯氏考克斯体利用IV型分泌系统（T4SS）来改变宿主内膜运输系统，以形成一种独特的、源自溶酶体的小生境，称为含伯氏考克斯体空泡（CCV）。尽管CCV具有溶酶体特性，但这个细胞器除了能与自噬体强烈相互作用外，还表现出一些独特的特征，如同型融合和富含胆固醇的限制膜。这篇综述描述了在理解CCV生物发生以及伯氏考克斯体维持这个独特区室所采用的机制方面的最新进展。
