Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Wasserturmstraße 3/5, D-91054 Erlangen, Germany.
Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Wasserturmstraße 3/5, D-91054 Erlangen, Germany.
Int J Med Microbiol. 2018 Jan;308(1):77-83. doi: 10.1016/j.ijmm.2017.09.010. Epub 2017 Sep 14.
Coxiella burnetii is an obligate intracellular and airborne pathogen which can cause the zoonotic disease Q fever. After inhalation of contaminated aerosols alveolar macrophages are taking up C. burnetii into a phagosome. This phagosome matures to a very large vacuole called the C. burnetii-containing vacuole (CCV). Host endogenous and bacterial driven processes lead to the biogenesis of this unusual compartment, which resembles partially a phagolysosome. However, there are several important differences to the classical phagolysosome, which are crucial for the ability of C. burnetii to replicate intracellularly and depend on a functional type IV secretion system (T4SS). The T4SS delivers effector proteins into the host cell cytoplasm to redirect intracellular processes, leading to the establishment of a microenvironment allowing bacterial replication. This article summarizes the current knowledge of the microenvironment permissive for C. burnetii replication.
贝氏考克斯体是一种专性细胞内和空气传播病原体，可引起人畜共患疾病 Q 热。吸入受污染的气溶胶后，肺泡巨噬细胞将 C. burnetii 摄取到吞噬体中。该吞噬体成熟为一个非常大的空泡，称为含 C. burnetii 的空泡（CCV）。宿主内源性和细菌驱动的过程导致这个异常隔室的发生，其部分类似于吞噬溶酶体。然而，与经典的吞噬溶酶体相比，它存在几个重要差异，这些差异对于 C. burnetii 在内质网内复制至关重要，并且依赖于功能性 IV 型分泌系统（T4SS）。T4SS 将效应蛋白输送到宿主细胞质中，以重新定向细胞内过程，从而建立允许细菌复制的微环境。本文总结了目前关于 C. burnetii 复制的微环境的知识。
