Arch Virol. 2013 Dec;158(12):2487-94. doi: 10.1007/s00705-013-1767-7.
Acute diarrhea outbreaks caused by porcine epidemic diarrhea virus (PEDV) have been observed in various pig-breeding provinces of China since December 2010. Endemic strains of PEDV were isolated from different areas, and the complete genome sequences of 10 isolates were determined. Our objective in this study was to genetically characterize current Chinese field isolates of PEDV to better understand their epidemiology and genetic diversity. Sequence analysis showed that 10 post-2010 isolates shared high homology with each other and were always clustered together with the virulent DR13 strains (South Korea) and/or one earlier Chinese strain, CH-S, in phylogenetic analysis. All post-2010 isolates possessed common sequence changes in each gene. Our results suggest that current Chinese PEDV isolates originated from either South Korean and/or Chinese ancestors that underwent some genetic variation, thereby forming a new PEDV genotype in China.
自 2010 年 12 月以来，中国多个养猪省份均观察到由猪流行性腹泻病毒（PEDV）引起的急性腹泻疫情。从不同地区分离到了地方性流行株，测定了 10 个分离株的全基因组序列。本研究旨在对当前中国流行的 PEDV 分离株进行遗传特征分析，以便更好地了解其流行病学和遗传多样性。序列分析显示，10 个 2010 年后的分离株彼此之间具有高度同源性，在系统进化分析中始终与强毒 DR13 株（韩国）和/或一个较早的中国分离株 CH-S 聚类在一起。所有 2010 年后的分离株在每个基因中都具有共同的序列变化。我们的结果表明，当前中国的 PEDV 分离株源自韩国和/或中国的祖先，经历了一些遗传变异，从而在中国形成了一种新的 PEDV 基因型。
